Pediatric Neurointensive Care and Resuscitation Research

 描述(由申请人提供)：儿童的急性威胁生命的侮辱，如创伤性脑损伤和心脏骤停(CA)是导致发病率和死亡率的主要原因。这些侮辱对中枢神经系统的损伤是不良结局的关键决定因素。这些神经和多系统的侮辱需要多学科和多部门的反应，必须从实地到康复都要协调。因此，儿科神经重症监护和复苏方面的研究培训最好是并行的多学科和多部门计划。我们在萨法尔复苏研究中心的独特博士后项目，自2000年以来由T32项目支持，在婴儿和儿童脑损伤的连续护理中建立了重要的联系，并促进了关键学科的严格科学调查，包括儿科重症监护医学、儿童神经病学、儿科神经外科、儿科急诊医学、新生儿学、儿科放射学和儿科康复医学。我们对这些儿科学科的研究员进行神经重症监护和复苏方面的基础和临床研究方面的培训，将他们与资深科学家联系起来。我们的T32计划在多元化招聘方面取得了成功，特别是在招聘残疾申请者方面。在这份重新提交的竞争性续签申请中，请拨资金以支持每年4个职位(一般为每年两名新学员)。自成立以来，该项目的每个职位都有高质量的研究员，他们发表了大量同行评议的论文和摘要，并获得了许多研究奖项。自4年前我们的上一次续签以来，3名毕业生获得了主要的国家资助，其中2人获得了他们的第一个R01奖，1人获得了PI的187万美元的多中心以患者为中心的结果研究所(PCORI)赠款。在过去的10年里，共有10名由我们的T32资助或明显与我们的T32有关联的研究员获得了11个K奖。在过去的10年里，我们的学员发表了61篇同行评审的论文(其中45篇是第一作者)，其中许多人获得了高级学位。他们作为教员受到了极大的追捧。研究重点是继发性损伤的细胞、分子和生化机制、新的治疗方法和结果，以及几个新的研究领域，如精确医学和比较有效性研究等。我们使用长椅到床边的方法，由我们的教员支持联邦政府资助的研究。我们利用萨法尔中心与匹兹堡儿童医院和匹兹堡大学医学院的培训项目之间的独特互动，并利用独特的资源和临床与转化科学研究所。每个导师的研究领域提出了适合职业发展和假设检验的重要问题。我们整合了神经重症监护的课程，并参与了最先进的儿科神经危重护理临床服务。毕业生可以设计、执行、分析、展示和发表旨在回答关键问题的实验，并接受研究的培训和负责任的研究。

 DESCRIPTION (provided by applicant): Acute life-threatening insults in children such as traumatic brain injury and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi-system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is thus best served by a parallel multidisciplinary and multi-departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000 establishes important links across the continuum of care of brain injury in infants and children and facilitate rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and pediatric rehabilitation medicine. We train fellows in these pediatric disciplines in both basic and clinical research in neurointensive care and resuscitation linking them to senior scientists. Our T32 program has had success in diversity recruitment specifically in recruiting applicants with disabilities. In this re-submitted competitive renewal application, funds are requested to support 4 positions each year (generally two new trainees each year). Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many research awards. Since our last renewal 4 years ago, 3 of the graduates have gone on to major national funding including 2 receiving their first R01 awards and one receiving as PI a $1.87M multi-center Patient Centered Outcomes Research Institute (PCORI) grant. In the past 10 years, a total of 10 fellows funded by or clearly associated with our T32 have received 11 K awards. In the past 10 years our trainees have published 61 peer-reviewed papers (45 as first author), and many have received advanced degrees. They are highly sought after as faculty. The research focus is on cellular, molecular and biochemical mechanisms of secondary injury, novel therapies, and outcomes along with several new areas of study such as precision medicine and comparative effectiveness research, among others. We use a bench to bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at the Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine and take advantage of unique resources and a Clinical and Translational Science Institute. The research areas of each mentor ask important questions suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a state-of-the-art pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present, and publish experiments designed to answer key questions and are trained in grantsmanship and responsible conduct of research.