National Biomedical NMR Resource at Madison

 描述(由申请人提供)：位于麦迪逊的国家磁共振设施(NMRFAM)是生物分子核磁共振(核磁共振)谱和小角X射线散射(SAXS)的资源中心。NMRFAM旨在通过资源技术和开发计划在以下重要领域扩大生物分子核磁共振谱的前沿：(1)高通量确定较小蛋白质和RNA分子的结构和功能；(2)研究具有挑战性的系统的结构和动力学技术，如复合体、膜蛋白质、顺磁蛋白质和大RNA分子；以及(3)代谢组学的有效方法，筛选与生物大分子结合的小分子，以及天然产物分析。NMRFAM致力于成为更大生物界的典范，展示核磁共振波谱的尖端能力。为了扩大其科学活动的范围，NMRFAM接待了与其研究技术开发项目相关领域工作的杰出来访科学家。通过合作活动，NMRFAM开发和传播涵盖生物分子核磁共振研究所有步骤的先进方法。该中心在以下一个或多个步骤中为生物医学核磁共振研究提供自始至终的支持：(1)策略评估和实验设计，(2)蛋白质和核酸的准备和标记，(3)可行性研究，(4)数据收集，(5)数据分析和结构确定，(6)数据沉积，和(7)手稿准备。NMRFAM旨在通过为研究人员提供与其特定需求相匹配的资源，促进对新知识的有效追求。一个主要目标是开发方法，使这些调查更快、成本更低，并适用于对人类健康具有重要意义的更大类别的蛋白质和核酸。NMRFAM为年轻的研究人员提供经验

 DESCRIPTION (provided by applicant): The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource center for biomolecular nuclear magnetic resonance (NMR) spectroscopy and small angle X-ray scattering (SAXS). NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, such as complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches to metabolomics, screening of small molecules binding to biological macromolecules, and natural product analysis. NMRFAM strives to be a model to the larger biological community for demonstrating cutting-edge capabilities of NMR spectroscopy. With the goal of broadening the scope of its scientific activities, NMRFAM hosts distinguished visiting scientists working in areas related to its research technology development projects. Through its collaborative activities, NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations. The center offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) preparation and labeling of proteins and nucleic acids, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data deposition, and (7) manuscript preparation. NMRFAM aims to facilitate the efficient pursuit of new knowledge by providing researchers with resources matched to their particular needs. A major goal is to develop methods for making these investigations faster and less costly as well as applicable to larger classes of proteins and nucleic acids of importance in human health. NMRFAM provides young investigators and experien