Role of human cervical mucus plugs in ascending GBS infection

项目摘要 导致人类新生儿发病和死亡的细菌感染仍然是重大的公共卫生问题 性问题B族链球菌（GBS）是革兰氏阳性菌，可导致早产、死胎和 人类新生儿的早期感染。虽然GBS通常作为浮游生物存在于 健康女性的下生殖道（LGT），促进GBS从LGT传播到 妊娠期间羊膜腔和胎儿未知。本提案的目的是界定 人宫颈粘液栓在预防GBS生长中的作用，并确定GBS是否能感知CMP 并改变毒力因子的表达，导致上行感染和胎儿损伤。

PROJECT SUMMARY Bacterial infections leading to morbidity and mortality of human newborns remain significant public health concerns. Group B Streptococci (GBS) are Gram-positive bacteria that cause preterm births, stillbirths and early onset infections in human newborns. Although GBS normally reside as commensal organisms in the lower genital tract (LGT) of healthy women, the events that promote transmission of GBS from the LGT to the amniotic cavity and fetus during pregnancy are unknown. The objective of this proposal is to define the role of the human cervical mucus plug in prevention of GBS growth and to determine if GBS sense CMP and modify virulence factor expression leading to ascending infection and fetal injury.