National Mesothelioma Virtual Bank, Continued Innovation

项目总结/摘要 国家间皮瘤虚拟银行（NMVB）同意患者提供生物标本 （血液制品和组织）以及人口统计学数据、职业史和临床 数据（阶段，治疗和生存信息）间皮瘤研究社区。的 匹兹堡大学（皮特）是协调中心，NMVB协议在 三个合作网站，纽约大学，罗斯韦尔公园癌症研究所和 宾夕法尼亚我们的具体目标是：1）继续为间皮瘤癌症研究服务 通过收集和分发组织，血液和上述数据以及 将NMVB队列增加至2400例患者。我们将继续记录和不断 评估NMVB对科学界的有用性，并衡量其在以下方面的影响 与间皮瘤应用研究基金会合作; 2）将NMVB扩展到 将马里兰州大学作为研究中心，并在 罗斯威尔公园癌症研究所我们还将增加默克研究实验室捐赠的350个病例; 以及3）通过提取临床、结果和结果来自动化生物样本的注释， 病理学数据来自电子健康记录和癌症登记系统。我们将部署和 实施可扩展的信息学解决方案，以最大限度地提高数据提取的有效性 跨合作地点的进程，将允许与其他国家组织和数据联系起来 共享网络。

Project Summary/Abstract The National Mesothelioma Virtual Bank (NMVB) consents patients to provide biospecimens (blood products and tissue) together with demographic data, occupational history and clinical data (stage, treatment and survival information) to the mesothelioma research community. The University of Pittsburgh (Pitt) is the coordinating site, and the NMVB protocol is in place at three partnering sites, New York University, Roswell Park Cancer Institute and University of Pennsylvania. Our specific aims are to: 1) Continue to serve the mesothelioma cancer research community by collecting and distributing tissue, blood and the aforementioned data as well as increasing the NMVB cohort to 2400 patients. We will continue to document and continually evaluate the usefulness of the NMVB to the scientific community and measure its impact in collaboration with the Mesothelioma Applied Research Foundation; 2) Expand the NMVB to the University of Maryland as a site and add fresh frozen tissue and blood product collection at Roswell Park Cancer Institute. We will also add 350 cases donated by Merck Research Labs; and 3) Automate annotation of biospecimens through extraction of clinical, outcomes, and pathology data from electronic health records and cancer registry systems. We will deploy and implement a scalable informatics solution to maximize the effectiveness of the data extraction process across collaborating sites which will allow linkage to other national tissue and data sharing networks.