Wake forest Clinical and Translational Science Award

联系PD/PI：李，国王C。 项目摘要/摘要 阻碍公共卫生进步的一个关键问题是我们所知道的可以改善的东西之间的鸿沟 健康以及在日常实践中实施的内容。此外，要产生最高的影响，多样化 参与者应参与所有类型的临床和转化性研究，以确保两者的相关性 向普通人群传播研究成果，以及传播这些成果以改进 以一种有意义的方式促进公共卫生。最后，研究成果的实施需要翻译 研究是在高效和有组织的环境中进行的。所有这些活动都对学习健康至关重要。 护理系统，为信息反馈循环、团队学习和调查提供基础， 利益相关者的参与、教育机会、持续改进和可持续性。这项使命 维克森林翻译科学研究所(TSI)的目标是提供一个创新、高效和可持续的 研究基础设施，以加速WF的转型，从而加快将发现转化为 改善健康状况。临床与翻译科学奖(CTSA)申请的目的是 协同TSI已经在维克森林浸信会带来的根本性积极变化 健康。TSI在发展和增加我们的翻译队伍方面已经取得了实质性的进展； 在生物统计学、流行病学和研究设计方面提供杰出的支持；并确保我们的研究 遵守监管准则，并符合道德标准。我们快速增长的临床集成 Network将从我们的附属机构收集数据，为以下方面提供非常丰富的临床信息来源 借助我们的生物医学信息学专业知识，提供新的研究方向。我们可以向CTSA提供 将我们的资源和专业知识联系起来，建立高效的临床研究支持计划和广泛的 进行多中心临床研究的经验，特别是以老年人为重点的研究，其中 我们的记录堪称典范。TSI也有社区参与、团队科学、 以及将特殊人群招募到翻译研究中。我们提出了新的实验方法 这将考验推进翻译科学科学的方法论。特别是，我们可以提供我们的 世界一流的能力，支持使用非人类灵长类模型进行具有高翻译价值的研究 为公众健康服务。在CTSA的支持下，我们可以利用这个全面的基础设施为新的试点项目提供资金 和新的多学科研究团队，并提供创新培训，帮助这些企业取得成功。尾迹 森林浸信会健康中心是一个完全集成的医疗中心，在其中治理、质量改进和 研究发现--包括这些发现可能产生的知识产权--是非常重要的 对齐了。总而言之，TSI准备成为CTSA网络中的一个富有成效的枢纽。 项目摘要/摘要页203 联系PD/PI：李，国王C。

Contact PD/PI: Li, King C. Project Summary/Abstract A critical issue that impedes advances in public health is the chasm between what we know can improve health and what is implemented in everyday practice. In addition, to have the highest impact, diverse participants should be involved in all types of clinical and translational research, to ensure both the relevance of research findings to the general population and the likelihood that they can be disseminated to improve public health in a meaningful way. Finally, implementation of research findings requires that translational research occurs in an efficient and organized environment. All of these activities are critical to a learning health care system by providing the foundation for information feedback loops, team-based learning and investigation, stakeholder participation, opportunities for education, continuous improvement, and sustainability. The mission of the Wake Forest Translational Science Institute (TSI) is to provide an innovative, efficient, and sustainable research infrastructure to accelerate WF's transformation, and thus speed the translation of discoveries to improve health. The purpose of this Clinical and Translational Science Award (CTSA) application is to synergize the fundamental positive changes that the TSI has already brought to bear at Wake Forest Baptist Health. The TSI has already made substantive progress to develop and augment our translational workforce; provide outstanding support in biostatistics, epidemiology, and research design; and assure that our research complies with regulatory guidelines and meets ethical standards. Our rapidly growing Clinically Integrated Network will aggregate data from our affiliates to provide an extraordinarily rich source of clinical information to inform new research directions, facilitated by our biomedical informatics expertise. We can offer to the CTSA network our resources and expertise in building efficient clinical research support programs and extensive experience in the conduct of multi-center clinical research, especially studies focused on older adults, in which our track record is exemplary. The TSI also has model programs in community engagement, team science, and recruitment of special populations into translational research. We propose novel experimental approaches that will test methodologies to advance the science of translational science. In particular, we can offer our world-class capabilities to support the use of nonhuman primate models for research of high translational value to public health. With CTSA support, we can use this comprehensive infrastructure to fund new pilot projects and new multidisciplinary research teams, and offer innovative training to help those ventures succeed. Wake Forest Baptist Health is a fully integrated medical center in which governance, quality improvement, and research discoveries – including the intellectual property that may result from those discoveries – are highly aligned. In summary, the TSI is poised to be a productive hub within the CTSA network. Project Summary/Abstract Page 203 Contact PD/PI: Li, King C.