Core C - Data Management, Biostatistics, and Bioinformatics Core

核心C：数据管理，生物统计学和生物信息学核心 核心领导人：沙龙X。谢 摘要/摘要：数据管理，生物统计学和生物信息学核心C 这里描述的数据管理、生物统计学和生物信息学核心（核心C）是 宾夕法尼亚大学医学院阿尔茨海默病核心中心（ADCC）。的 核心C的目标在这个竞争性的更新申请继续资助宾夕法尼亚州ADCC的国家 老龄化研究所（NIA）是支持数据管理，统计，生物信息学，数据库，和相关的 宾夕法尼亚州ADCC研究人员和ADCC试点获奖者的计算需求。Core C提供的服务 包括：（a）支助数据表格/调查表设计和编制、数据库开发， 管理、数据输入、数据库审计跟踪、数据库安全、数据库备份和严格的数据质量 控制程序，（B）对所有宾夕法尼亚州ADCC活动的计算和编程支持，包括 实施和整合数据管理所需的硬件和软件升级， 对宾夕法尼亚州ADCC中心的计算系统进行研究、例行和归档异地备份，（c） 从研究开始到发表的所有研究方面的生物统计支持，包括研究设计的开发， 进行样本量和功效计算，并对ADCC数据进行分析，（d）提供 对ADCC受训人员进行统计培训，（e）促进宾州ADCC之间的有效工作关系， 其他NIA资助的AD中心（ADC）和国家阿尔茨海默氏症协调中心（NACC）。核心C 在宾夕法尼亚州ADCC中发挥着重要而重要的作用，这对AD及相关研究至关重要。 由Penn ADCC进行的轻度认知障碍（MCI）受试者和正常对照（NC） 研究人员及其合作者在其他ADC以及继续有效的工作 与NACC的关系。

Core C: Data Management, Biostatistics, and Bioinformatics Core Core Leader: Sharon X. Xie Summary/Abstract: Data Management, Biostatistics, and Bioinformatics Core C The Data Management, Biostatistics, and Bioinformatics Core (Core C) described here is an integral part of the University of Pennsylvania School of Medicine (Penn) Alzheimer's Disease (AD) Core Center (ADCC). The goal of Core C in this competing renewal application for continued funding of the Penn ADCC by the National Institute of Aging (NIA) is to support the data management, statistical, bioinformatics, database, and related computational needs of Penn ADCC investigators and ADCC Pilot awardees. The services provided by Core C include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all Penn ADCC activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the Penn ADCC, (c) biostatistical support for all study aspects from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the ADCC data, (d) provide statistical training to ADCC trainees, (e) promoting an effective working relationship between the Penn ADCC, other NIA funded AD Centers (ADCs) and the National Alzheimer's Coordinating Center (NACC). Thus, Core C plays an important and significant role in the Penn ADCC that is critical to research on AD and related disorders, subjects with mild cognitive impairment (MCI) and normal controls (NC) conducted by Penn ADCC investigators and their collaborators at other ADCs as well as to the continuation of an effective working relationship with NACC.