Fourier Ptychographic Endoscopy

 描述（由申请人提供）：为了解决薄型临床内窥镜的尺寸、分辨率和视场（FOV）之间的固有权衡，我们提出了一种基于傅立叶重叠关联成像（FP）技术的新型重叠关联成像内窥镜。重叠关联内窥镜使用角度变化的照明来扩展由光学系统限定的极限之外的性能。它具有以下主要特点：（1）重叠关联内窥镜系统可达到的分辨率由最大入射角决定，而不是由所采用的微型光学器件的数值孔径（NA）决定;（2）可以恢复高分辨率的样品图像并校正所采用的光学器件的剩余像差，从而实现更大的设计空间;（3）在不同深度处恢复的高分辨率图像可以用于构建组织拓扑结构的3D图像;以及（4）在连续照明下，该仪器作为常规的低分辨率内窥镜工作。当需要高分辨率成像时，它工作在FP模式下，具有顺序脉冲照明。本计画的目标是发展薄型内视镜及影像重建演算法，以展示重叠关联内视镜系统，其目标如下：（1）发展使用小型化光学元件及照明光纤的重叠关联内视镜系统（1-14个月）;（2）开发高速图像构建平台，以真实的实时构建大视场和大景深的高分辨率图像（1-15个月）;和（3）表征和评价重叠关联内窥镜系统的成像性能（14-24个月）。重叠关联内窥镜结构紧凑，不需要复杂的系统，而且由于只需要一个环形照明光源，所以成本低。最重要的是，它解决了薄型内窥镜的尺寸、分辨率和FOV之间的固有权衡。成功完成拟议的重叠关联内窥镜将使我们能够开发薄内窥镜，以满足未满足的临床需求，使临床医生能够准确地检测和诊断疾病，特别是在访问受限的地区。

 DESCRIPTION (provided by applicant): To address the inherent trade-offs between the size, resolution, and field of view (FOV) of thin clinical endoscopes, we propose a novel ptychographic endoscope based on the Fourier ptychography (FP) technology. Ptychographic endoscope uses angularly varying illumination to extend the performance beyond the limit defined by the optical system. It has the following key features: (1) the achievable resolution of ptychographic endoscopy system is determined by the largest incident angle, not the numerical aperture (NA) of the employed miniaturized optics; (2) it is possible to recover the high resolution sample image and correct for remaining aberrations of the employed optics, enabling a much larger design space; (3) the recovered high-resolution images at different depths can be used to construct a 3D image of the tissue topographic structure; and (4) with continuous illumination, the instrument works as a conventional low resolution endoscope. When high resolution imaging is needed, it works in FP mode with sequential pulse illuminations. The goal of this proposal is to develop thin endoscope and image reconstruction algorithms to demonstrate the ptychographic endoscopy system, by pursuing the following aims: (1) develop the ptychographic endoscopy system using miniaturized optics and illumination fibers (Month 1-14); (2) develop a high speed image construction platform to construct a high-resolution image over large FOV and large depth of field in real time (Month 1-15); and (3) characterize and evaluate the imaging performance of the ptychographic endoscopy system (Month 14-24). Ptychographic endoscope is compact and doesn't require a complicated system, it is also low cost because only a ring illumination source is needed. Most important, it addresses inherent trade-offs between the size, resolution, and FOV of thin endoscopes. Successful completion of the proposed ptychographic endoscope will enable us to develop thin endoscopes for unmet clinical needs by enabling clinicians to accurately detect and diagnosis diseases, particularly in regions with limited access.