Ultra Precision Nanotech Manufacturing System 140GPM

 产品说明：该提案旨在为从摩尔纳米技术系统有限责任公司购买纳米技术140 GPM精密玻璃压制成型设备提供资金，以支持NIH资助的项目。这种最先进的仪器将大大提高我们快速制作光学设备原型的能力，以加快NIH资助项目的进展，并扩展我们开发用于生物成像和临床应用的新光学技术的能力。纳米技术140 GPM，目前还没有在亚利桑那大学（UA），可以生产新颖和复杂的玻璃微光学元件，这是必不可少的高图像质量和高通量的生物医学成像技术，但不能通过传统的研磨/抛光方法制造。微光学器件、透镜阵列、非球面透镜、自由曲面光学器件和微流体微结构是一些只有要求的设备才能制造的例子，以加快UA的NIH资助的项目，并拓宽UA生物医学成像研究的视野。为了支持和补充纳米技术140 GPM，光学科学学院致力于建立一个国家的最先进的精密光学设施，致力于开发，设计，制造，测试和教育的光学成像技术和设备的生物医学应用。该设施将包括本提案中提出的140 GPM精密玻璃压模机，学院承诺购买的Nanotech 350 FG自由成型发生器，以及学院目前可用的3D光学表面轮廓仪。该设施将提供一个平台， 用于快速原型新颖的医学和生物成像系统，并将使我们能够探索新的设计空间，制造和测试以前没有的光学元件和系统。所要求的仪器支持的研究项目涵盖基础和转化研究领域，包括用于诊断癌症的显微内窥镜，多模式成像，微流体系统，高光谱成像，用于诊断食管病理的显微内窥镜，图像引导手术，高分辨率多色FLIM-FRET断层扫描等。在这个专用设施中开发的设计方法，制造和测试技术将大大有利于整个生物医学光学成像社区的研究人员。该设施还将为培养下一代跨学科科学家和工程师提供一个极好的机会，无论是本科生还是研究生。

 DESCRIPTION: This proposal seeks funding for the purchase of the Nanotech 140GPM precision glass press molding equipment from Moore Nanotechnology Systems LLC to support NIH funded projects. This state-of-the-art instrument will greatly enhance our capabilities to rapidly prototype optical devices to accelerate progress of NIH-funded projects and extend our capabilities in developing new optical technologies for bio-imaging and clinical applications. Nanotech 140GPM, currently not available at University of Arizona (UA), can produce novel and complex glass micro optical elements which are essential for high image quality and high throughput biomedical imaging technologies, but cannot be fabricated by traditional grinding/polishing methods. Micro- optics, lens array, aspherical lens, freeform optics, and microfluidic microstructures are some examples that only the requested equipment can fabricate to speed up UA's NIH-funded projects and broaden the horizons of biomedical imaging research at UA. To support and to complement the Nanotech 140GPM, College of Optical Sciences committed to build a state- of-the-art precision optics facility dedicated to development, design, fabrication, testing and education of optical imaging technologies and devices for biomedical applications. This facility will include 140GPM precision glass press molding machine proposed in this proposal, Nanotech 350FG freeform generator the College committed to purchase, and 3D optical surface profilers current available at the College. The facility will provide a platform for rapid prototyping novel medical and biological imaging systems and will enable us to explore new design spaces, fabricate and test optical components and systems which have not been previously available. The research projects supported with the requested instrument covers both basic and translational research areas, including microendoscope for diagnosis of cancer, multimodal imaging, microfluidic system, hyperspectral imaging, microendoscope for diagnosis of Esophageal pathology, image guide surgery, high- resolution multi-color FLIM-FRET tomography, and others. The design methodologies, fabrication and testing technologies developed in this dedicated facility will greatly benefit researchers over the entire community of biomedical optical imaging. This facility will also provide an excellent opportunity to train the next generation of interdisciplinary scientists and engineers, at both the undergraduate and graduate levels.