Chronic Effects of Neurotrauma Consortium (CENC) Epidemiology Study

该项目的主要目标是通过集成和 以新颖的方式分析它们，以回答与轻度创伤性脑损伤的慢性影响相关的关键问题 随着时间的推移，退伍军人的伤害(MTBI)。尽管先前的研究发现，中度和重度脑外伤是 与各种不良临床结局相关，mTBI的影响还不是很清楚。我们 建议通过四个相辅相成的具体目标来解决这一知识差距。在目标1中，我们建议 检查mTBI与重要的短期临床结果之间的关系，如事故和 最近伊拉克和阿富汗冲突中退伍军人的受伤情况，重点是确定相关因素 具有恢复力和适当治疗的潜在好处。在目标2中，我们建议扩大这些 分析包括所有时代的退伍军人，并研究包括神经感觉在内的长期临床结果 疾病和死亡率，重点关注并存的医疗条件和 对他们治疗的影响。在目标3中，我们建议确定与mTBI相关的不同并存的轨迹 负担，目的是确定与处于低和高痛苦轨迹相关的因素。最后，在 目标4，我们建议通过以下方式，使用更详细和统一的mTBI数据为未来的分析奠定基础 为创建国家CENC数据存储库(NCDR)开展基础工作。这些目标加在一起，将 增进我们对不同年龄和年龄的退伍军人mTBI对重要临床结局的影响的了解 并将为潜在的预防和干预战略提供洞察。

The primary objective of this project is to capitalize on a variety of existing data sources by integrating and analyzing them in novel ways to answer key questions related to the chronic effects of mild traumatic brain injury (mTBI) in Veterans over time. Although prior studies have found that moderate and severe TBI are associated with a variety of adverse clinical outcomes, the effects of mTBI are less well understood. We propose to address this gap in knowledge through four complimentary Specific Aims. In Aim 1, we propose to examine the association between mTBI and important shorter-term clinical outcomes such as accidents and injuries in Veterans from recent conflicts in Iraq and Afghanistan, focusing on identifying factors associated with resilience and the potential benefits of adequate treatment. In Aim 2, we propose to expand these analyses to include Veterans from all eras and to study longer-term clinical outcomes including neurosensory disorders and mortality, focusing on the potential confounding effects of comorbid medical conditions and the impact of their treatment. In Aim 3, we propose to identify different trajectories of mTBI-related comorbid burden, with the goal of identifying factors associated with being in low and high distress trajectories. Finally, in Aim 4, we propose to lay the groundwork for future analyses using more detailed and unified mTBI data by developing the groundwork to create a National CENC Data Repository (NCDR). Together, these Aims will advance our knowledge of the effects of mTBI on important clinical outcomes in Veterans of all ages and eras in a highly efficient manner and will provide insight into potential strategies for prevention and intervention.