Phase III COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine

描述(由申请人提供)：这是一份在我们从成功的11期状态过渡到11期发展的关键阶段时，继续为我们的干细胞和祖细胞生物学和再生医学Cobre提供NIH/NIGMS支持的建议。主要目标是：i)继续推进干细胞和祖细胞生物学方面与生物医学相关的主题性发现；ii)保持和扩大强大的内部和外部咨询委员会和支持机制，以专业地指导研究人员、研究员、学生和核心工作人员；iii)实施试点项目计划，以跳板非常有希望的发现，为国家资金和影响出版物；iv)与我们高度支持的医学中心和研究所合作，招聘更多强大的科布雷中心研究人员；v)继续提高我们中心研究核心设施的专业知识、效率、实用性和自我维持性。在第二阶段，我们在我们的学科中进一步推进了有影响力的发现，在优秀的期刊上发表了研究，指导和推进了中心的调查，招募了强大的新调查人员，并在获得独立的国家资金方面取得了明显的成功。在基础设施和机构支持方面也取得了显著进展。这些措施包括建造一个新的研究部门，正在招聘更多的科学家，推进现有的核心设施，以及开发一个亟需的生理学核心。在第三阶段，PI将由一名合作调查员(L.Oxburgh，PhD， DVM Cobre成员(自2005年起)和计划协调员(E.Jachimowicz)。我们的行政核心将实施杰出种子研究的试点项目计划，并推进新的转化研究机会；干细胞和祖细胞生物学的核心研讨会和夏季研讨会；受邀的研讨会系列；以及招聘一名磁铁临床科学家。核心设施也将得到加强。分子表型核心侧重于基因表达的定量分子分析和细胞显微镜。组织病理学核心提供专家组织学支持，以及涉及人类病理学研究和小鼠基因突变的新合作。我们的祖细胞分析核心提供流式细胞仪分析、细胞分类、克隆细胞分析和干细胞/祖细胞培养服务。我们的新生理学核心将提供最先进的代谢表型、骨骼成像和细胞能量分析。还确定了实现第二阶段后核心和中心自给自足的具体计划。

DESCRIPTION (provided by applicant): This is a proposal for continued NIH/NIGMS support for our COBRE in Stem & Progenitor Cell Biology and Regenerative Medicine as we transition from successful Phase-ll status to a critical stage of Phase-Ill development. Prime goals are: i) Continue to advance thematic, biomedically relevant discoveries in stem and progenitor cell biology; ii) Sustain and extend strong internal and external advisory committees and supporting mechanisms to expertly mentor investigators, fellows, students and core staff; iii) Implement a Pilot Project Program to springboard highly promising discoveries towards national funding and impacting publications; iv) Work with our highly supportive Medical Center and Research Institute to recruit additional strong COBRE Center investigators; v) Continue to sharpen the expertise, efficiency, utility and selfsustaining nature of our Center's Research Core Facilities. During Phase-ll, we have further advanced impacting discoveries in our discipline, published studies in excellent journals, mentored and advanced Center investigations, recruited strong new investigators, and demonstrated clear success in securing independent national funding. Gains in infrastructure and Institutional support also are significant. These include the construction of a new research wing, the ongoing recruitment of additional scientists, the advancement of existing core facilities, and the development of a highly needed Physiology Core. In Phase-Ill, the PI will be assisted administratively by a co-lnvestigator (L. Oxburgh, PhD, DVM COBRE member since 2005) and Program Coordinator (E. Jachimowicz). Our administrative core will implement a Pilot Project Program for outstanding seed investigations, and to advance new translational research opportunities; a core workshop and summer symposium in Stem & Progenitor Cell Biology; an invited seminar series; and the recruitment of a magnet clinician scientist. Core facilities also will be enhanced. The Molecular Phenotyping Core focuses on quantitative molecular analysis of gene expression and cellular microscopy. The Histopathology Core provides expert histological support plus new collaborations involving human pathology studies, and mouse genetic mutants. Our Progenitor Cell Analysis Core provides flow cytometric analyses, cell sorting, clonal cell analyses and stem/progenitor cell culture services. Our new Physiology Core will provide state-of-the-art metabolic phenotyping, skeletal imaging and cell energetic analyses. Specific plans towards Core and Center self-sufficiency post- Phase-Ill also are defined.