International Research Collaboration on Neuroimaging Studies of Alcoholism

描述（由申请人提供）：本申请的U 01合作协议奖的竞争性续期是写在响应计划公告（PA）编号PAR-11-282，“国际研究合作酒精和酒精中毒。“获得这一奖项将使我们能够继续在法国卡昂大学的弗朗西斯尤斯塔什博士指导下，最近在韩国首尔的延世大学附属塞弗伦斯医院建立的成瘾研究项目，由医学博士Young-Chul Jung指导，哲学博士、以及我们长期的神经成像和神经科学实验室，主要由NIAAA资助，位于美国斯坦福大学，Edith Sullivan博士，主要研究者（MPI）和SRI International与Adolf Pfefferbaum，M.D.（MPI）。这项合作的首要目标是：1）使用神经成像，神经心理学和营养生物标志物在酗酒者中，有和没有KS，以及对照，比较和对比酒精对各国大脑结构和功能的影响，2）识别 营养状况、遗传变异和酒精消费模式，这些因素调节了主要的依赖性指标，并解释了酒精中毒表现和恢复的异质性。提出了三个具体的目标与可检验的假设：1。在每个国家-美国，用常见的DSM-V诊断标准进行预防性筛查，100名酗酒者，100名对照者和10名KS，法国和韩国，并获得以下数据：1a.神经成像（MRI，FLAIR，DTI和rs-fMRI）数据使用在当前资助期间开发的通用协议。1b.神经心理学数据使用常见的长期和新开发的短期测试电池。1c.用于分析营养状况生物标志物的血液（红细胞计数、红细胞压积、血红蛋白、平均红细胞体积的血象;维生素B1（全血二磷酸硫胺素）、叶酸、B12和脑血管风险因子（同型半胱氨酸）。1.d.用于硫胺素转运蛋白基因分型分析的血液2。实施一个安全的管道，用于数据的接收、存储、分析和向项目现场的传播。3.与项目科学家（访问美国的法国和韩国科学家以及访问法国和韩国的美国科学家）合作进行数据分析和假设检验，并将结果和分析程序出口到法国和韩国。

DESCRIPTION (provided by applicant): This application for a competing renewal of a U01 cooperative agreement award is written in response to Program Announcement (PA) number PAR-11-282, "International Research Collaboration on Alcohol and Alcoholism." Receipt of this award would enable us to continue a program of international collaborations among the well-established nationally funded research groups at INSERM/University of Caen site in France directed by Francis Eustache, Ph.D., the recently-established addictions research program at the Yonsei University affiliated Severance Hospital in Seoul, South Korea directed by Young-Chul Jung, M.D., Ph.D., and our longstanding neuroimaging and neuroscience laboratories funded principally by NIAAA, in the United States at Stanford University with Edith Sullivan, Ph.D., Principal Investigator (MPI) and at SRI International with Adolf Pfefferbaum, M.D. (MPI). The overarching aim of this collaboration is 1) to use neuroimaging, neuropsychology, and biomarkers of nutrition in alcoholics, with and without KS, and controls to compare and contrast the effects of alcohol on brain structure and function across nations and 2) to identify markers of nutritional status, genetic variants, and alcohol consumption patterns that modulate the principal dependent measures and explain heterogeneity in presentation and recovery of alcoholism. Three specific aims with testable hypotheses are proposed: 1. Prospectively screen with common diagnostic DSM-V criteria 100 alcoholics, 100 controls, and 10 KS in each country-U.S., France, and South Korea-and acquire the following data: 1a. Neuroimaging (MRI, FLAIR, DTI, and rs-fMRI) data using common protocols developed over the current funding period. 1b. Neuropsychological data using the common long and newly developed short test batteries. 1c. Blood for analysis of biomarkers of nutritional status (hemogram for red blood cell count, hematocrit, hemoglobin, mean corpuscular volume; vitamin B1 (whole blood thiamine diphosphate), folate, B12 and cerebrovascular risk factor (homocysteine). 1.d. Blood for analysis of thiamine transporter genotyping 2. Implement a secure pipeline for data reception, storage, analysis, and dissemination to and from project sites. 3. Conduct data analysis and hypothesis testing in collaboration with the project scientists (French and Korean visiting the U.S. and U.S. visiting France and Korea) and export results and analysis procedures to France and Korea.