Colorado Nutrition Obesity Research Center

 描述（由申请人提供）：整体组成部分这是一个申请5年的竞争性更新的科罗拉多营养肥胖研究中心（NORC）。NORC的广泛目标是支持和加强正在进行的营养/肥胖研究，并促进科罗拉多NORC研究基地成员之间的跨学科合作和垂直整合研究。我们现在是在我们的第二十个年头的运作和NORC支持超过96个定期和16个指导研究人员在研究基地谁产生超过43，000，000美元，每年的营养/肥胖研究的直接成本。NORC的资源已被利用，以确保超过70，000，000美元（不包括个人研究赠款），以支持科罗拉多大学的营养/肥胖研究。NORC支持的研究范围从细胞和分子到临床研究再到社区研究。我们已经承诺在我们的研究基地内培养团队科学，因为我们相信这是我们NORC发展的合乎逻辑的下一步-使用NORC资源创建和支持研究团队，以解决可以通过跨学科，协作方法最好地解决的重大和重要的研究问题。我们的研究基地围绕4个研究小组组织- 1）肥胖的母亲-胎儿起源; 2）代谢、衰老、性别和运动调查（IMAGE）; 3）体重管理; 4）肥胖和代谢失调。这些团队已经成功地为团队科学筹集了额外的资源。该研究基地由3个科学核心支持，支持基础，临床和社区研究人员：1）分子和细胞分析; 2）能量平衡评估; 3）临床干预和翻译。科罗拉多NORC有强大的领导与博士詹姆斯O。Hill继续担任NORC主任，Dan Bessesen博士和Paul MacLean博士担任副主任。科罗拉多NORC位于安舒茨健康中心（AHWC）内，该中心位于科罗拉多大学医学院内。AHWC的一项使命是促进研究翻译，AHWC设施为NORC的研究翻译提供了机会。我们的试点和可行性计划非常成功，帮助我们的新研究人员发展成为独立的研究人员和营养/肥胖的国家领导人。我们的丰富计划已经成功地帮助促进合作，并在丰富其他卫生保健专业人员和社区在营养和肥胖领域。在其第二十个年头，科罗拉多NORC是公认的和备受尊敬的世界领先的中心之一，营养和肥胖研究和研究翻译。

 DESCRIPTION (provided by applicant): Overall Component This is an application for a 5 year competitive renewal for the Colorado Nutrition Obesity Research Center (NORC). The broad goal of the NORC is to support and enhance ongoing nutrition/obesity research and to promote interdisciplinary collaborative, vertically integrated research among members of the Colorado NORC research base. We are now in our twentieth year of operation and the NORC supports over 96 regular and 16 mentored investigators in the research base who generate over $43,000,000 per year in direct costs for nutrition/obesity research. The resources of the NORC have been leveraged to secure over $70,000,000 (not counting individual research grants) in support for nutrition/obesity research at the University of Colorado. The research supported by the NORC ranges from cellular and molecular to clinical research to research in the community. We have made a commitment to foster team science within our research base because we believe this is the logical next step in the evolution of our NORC - to use NORC resources to create and support research teams to address big and important research questions that can best be addressed via an interdisciplinary, collaborative approach. We have organized our research base around 4 research team - 1) Maternal-Fetal Origins of Obesity; 2) Investigations in Metabolism, Aging, Gender, and Exercise (IMAGE); 3) Weight Management; 4) Obesity and Metabolic Dysregulation. These teams have already been successful in raising additional resources for team science. The research base is supported by 3 scientific cores that support basic, clinical and community researchers: 1) Molecular & Cellular Analytical; 2) Energy Balance Assessment; 3) Clinical Intervention and Translation. The Colorado NORC has strong leadership with Dr. James O. Hill continuing to serve as NORC Director and Drs. Dan Bessesen and Paul MacLean serving as Associate Directors. The Colorado NORC is located within the Anschutz Health and Wellness Center (AHWC) which is located within the University of Colorado, School of Medicine. A mission of the AHWC is to promote research translation and AHWC facilities provide an opportunity for translation of research emanating from the NORC. Our pilot and feasibility program has been extremely successful in helping develop our new investigators into independent researchers and national leaders in nutrition/obesity. Our enrichment program has been successful in helping promote collaboration and in enriching other health care professionals and the community in the areas of nutrition and obesity. In its twentieth year, the Colorado NORC is well recognized and well respected as one of the leading centers in the world for nutrition and obesity research and research translation.