Research Training in the Neuroscience of Aging

 描述(由申请者提供)：拟议的老年神经科学研究培训计划将为神经科学博士前学生提供在国内和国际公认的教师的实验室进行综合培训的经验。博士前培训计划建立在研究生院第一年和第二年教授的令人兴奋的、与翻译相关的课程基础上，该课程通过联合发起的博士前早期T32培训计划机制(T32 MH087004)获得了NIH的支持。拟议的新培训计划将是西奈山第一个专门专注于衰老和与年龄相关的神经退行性疾病(主要是阿尔茨海默病)神经科学的培训计划，补充了西奈山在这些领域的历史专注和研究实力。在拟议的项目中，优秀的培训人员在健康和疾病中的大脑功能机制方面有着共同的研究兴趣，他们采用了多种实验方法，并在从分子神经生物学到人类神经心理学和神经成像的分析水平上工作。该培训计划特别鼓励教师导师的参与，他们的研究拨款直接专注于老化的神经科学研究，同时不排除那些研究专长对我们寻求传授的跨学科培训至关重要的人。通过他们的课程工作，博士前实习生将获得基础神经生物学和神经和精神疾病的病理生理学，以及生物统计学和负责任的研究指导。高级课程包括关于衰老生物学的研讨会课程，以及神经科学特定领域的重点选修课。研究导师的选择是在积极促进多学科、综合研究的协作环境中进行的。研究培训还将有一个“正在进行的工作”部分，以促进重要的跨学科互动，磨练陈述技能，并提高对道德问题的认识。使用这种方法，老年神经科学研究培训计划将在我们培训教师的实验室为博士前学生提供指导和实验工具，以在老龄研究领域开展成功、富有成效的独立职业生涯。

 DESCRIPTION (provided by applicant): The proposed program on Research Training in the Neuroscience of Aging will provide predoctoral students in Neuroscience with an integrated training experience in the laboratories of nationally and internationally recognized faculty. The predoctoral training program builds on an exciting, translationally relevant curriculum taught in years one and two of graduate school that has been awarded NIH support through the Jointly Sponsored Predoctoral Early Stage T32 Training Program mechanism (T32 MH087004). The proposed new training program would be the first at Mount Sinai to focus specifically on the neuroscience of aging and age- related neurodegenerative disease (primarily Alzheimer's disease), complementing Mount Sinai's historical concentration and strength in research in these areas. Outstanding training faculty in the proposed program share common research interests in the mechanisms of brain function in health and disease, employing a diversity of experimental approaches and working at levels of analysis ranging from molecular neurobiology to human neuropsychology and neuroimaging. The training program specifically encourages participation of faculty mentors whose research grants directly focus on aging neuroscience research, while not excluding those whose research expertise is critically important for the interdisciplinary training we seek to impart. Through their course work, predoctoral trainees will have received a solid foundation in basic neurobiology and the pathophysiology of neurological and psychiatric disease, as well as biostatistics and the responsible conduct of research. Advanced coursework includes a seminar course on the biology of aging as well as focused elective courses in specific areas of neuroscience. Selection of a research mentor is made in a collaborative environment that actively promotes multidisciplinary, integrative research. Research training will also have a `work in progress' component, to foster important interdisciplinary interactions, hone presentation skills, and improve awareness of ethical issues. Using this approach, the program on Research Training in the Neuroscience of Aging will provide predoctoral students with the guidance and experimental tools, in the laboratories of our training faculty, to launch successful, productive, independent careers in aging research.