Boston University/Lata Medical Research Foundation and Indira Gandhi Government Medical Center Global Network for Women's Children's Health Research Unit

项目总结/摘要 波士顿大学全球网络（GN）研究中心（RU）和英迪拉·甘地政府医疗中心（Indira Gandhi Government Medical Center） 学院（IGGMC）/拉塔医学研究基金会（LMRF）在纳格布尔，印度正在申请重新- NICHD的全球妇女和儿童健康研究网络的竞争，继续他们的 参与GN研究使命。由于位于印度东部的那格浦尔的RU 马哈拉施特拉邦的新生儿和婴儿死亡率高于印度的总体死亡率， 改善RU集水区母亲及其婴儿健康状况的重要需求。的RU 在领导和开展国际多中心合作临床试验方面拥有丰富的经验， 执行科学研究，致力于提供证据，说明改善孕产妇和 儿童健康在需要的人群中。RU的其他优势包括其招募> 10，000人的能力 妊娠女性/年进入GN研究，保留率> 99%，并指导初级研究者。 纳格布尔RU在未来五年的目标是双重的。第一个目标是继续参与 在妇女和儿童人群中开展的多中心、高影响力、成本效益、大规模临床研究， 是全球死亡和残疾人数最多的国家。第二个目标是加强对初级教育的指导， 研究人员提高他们的研究能力和出版记录，并支持他们的能力， 成功地竞争赠款，研究重要的公共卫生干预措施。RU的具体目标是 （1）制定战略，继续纳格布尔RU的增长和发展，并维持 支持纳格布尔学术界公共卫生研究的设计和实施的研究基础设施 （2）加强对妊娠期发病率和死亡率主要原因的研究， （3）为尼泊尔政府提供支持，以继续确定和 解决孕产妇和儿童研究方面的差距。 纳格布尔RU建议通过继续与GN合作来实现其目标和具体目标， 针对知识方面的关键差距，实施科学合理和严格设计的共同协议， 在资源有限的环境中改善母亲及其婴儿的健康结果。纳格布尔RU 将继续为GN贡献科学专业知识，特别是在纳格布尔的具体优势领域 RU，包括儿科、泌尿科、感染性疾病（儿童肺炎/新生儿败血症/腹泻）， 环境暴露，特别是家庭空气污染、营养/营养不良、产科和 新的移动医疗干预措施，用于产科和儿科发病率和并发症的护理点诊断。

Project Summary/Abstract The Global Network (GN) Research Unit (RU) of Boston University and the Indira Gandhi Government Medical College (IGGMC)/Lata Medical Research Foundation (LMRF) in Nagpur, India are applying to the re- competition of NICHD’s Global Network of Women and Children’s Health Research to continue their participation in GN research mission. Since the Nagpur-based RU in the eastern part of the Indian state of Maharashtra has neonatal and infant mortality rates that are higher than overall rates in India, there is an important need to improve health outcomes of mothers and their infants in the RU catchment area. The RU has extensive experience in leading and conducting international multicenter collaborative clinical trials and implementation science research dedicated to generating evidence on the best ways to improve maternal and child health in its population in need. Additional strengths of the RU include its ability to recruit >10,000 pregnant women/year into GN studies with > 99% retention rates, and mentoring of junior investigators. The goals of the Nagpur RU over the next five years are twofold. The first goal is to continue to participate in multicenter, high impact, cost-effective, large scale clinical studies in populations of women and children that have the highest burden of death and disability globally. The second goal is to augment the mentoring of junior researchers to improve their research capacity and publication records and to support their ability to successfully compete for grants to study important public health interventions. The specific aims of the RU are to: (1) develop strategies to continue the growth and development of the Nagpur RU and to sustain the research infrastructure that supports the design and conduct of public health research in the Nagpur academic institutions; (2) strengthen research focused on the leading causes of morbidity and mortality in pregnancy and early childhood in the GN and in the Nagpur area; (3) provide support to the GN to continue to identify and address gaps in maternal and child research. The Nagpur RU proposes to achieve their goals and specific aims by continuing to collaborate with the GN in conducting scientifically justified and rigorously designed common protocols targeting key gaps in knowledge, relating to improving health outcomes in mothers and their infants in resource-limited settings. The Nagpur RU will continue to contribute scientific expertise to the GN, particularly in areas of specific strength in the Nagpur RU, including pediatrics, neonatology, infectious diseases, (childhood pneumonia/neonatal sepsis/diarrhea), environmental exposures, particularly household air pollution, nutrition/malnutrition, obstetrics and testing of novel mHealth interventions for point-of-care diagnosis of obstetric and pediatric morbidity and complications.