Clinical and Translational Science Award

爱因斯坦-蒙特菲奥雷临床和翻译研究所(卢旺达问题国际法庭)在过去两年中不断发展。 CTSA资助期，涵盖广泛的临床和转化(C/T)生物医学研究 从T1到T4。我们为我们的临床医生和我们的集成医疗系统提供了 扩大实施科学、人口健康、社区参与的研究和临床试验，同时 鼓励基础科学家创新新的治疗和诊断方法。我们与我们的广泛合作 社区和调查人员允许CTSA影响从药物到药物的广泛研究 设计和改进临床试验管理，培养新的研究队伍，并使用 社区参与和医疗保健研究的实施科学。事实上，卢旺达问题国际法庭的使命-- 通过其集成的基础设施将跨翻译光谱的研究推进到临床实践中， 创新培训和机构联合投资--与国家创新中心同步发展 翻译科学进阶。在此应用程序中，我们将1)利用CTSA资源与机构 支持最先进的信息学的资产，可通过 证据生成框架，支持法规精简、创新分析，并协助 C/T研究阶段；2)发展下一代研究人员和团队，使用新颖的 教育、培训、指导、试点研究支持和职业发展资源，涵盖翻译 域；3)扩大与CTSA网络和其他集线器以及 布朗克斯社区和医疗保健合作伙伴在协作中制定战略的综合模式 与社区合作伙伴、调查人员和机构领导层一起改善人口健康；4)推进 跨性别和特殊人群的寿命、儿童健康和老龄化研究，通过与独特的 利益相关者参与研究、患者安全和实施科学的平台，Montefiore 责任关怀组织和纽约市实践研究网络；以及5)创新 促进C/T科学，提高C/T的质量、安全和效率的方法和过程 研究。我们将把CTSA试验创新网络整合到我们的多站点临床试验生态系统中， 促进生物标记物分析和精准医学生物库的创新方法，并利用CTSA 共同指标计划，以支持我们中心的评估和战略管理。总的来说，爱因斯坦- 蒙蒂菲奥里卢旺达问题国际法庭将履行NCATS创新、教育和执行的三方使命。

The Einstein-Montefiore Institute for Clinical and Translational Research (ICTR) has evolved over the past two CTSA funding periods, embracing the broad spectrum of clinical and translational (C/T) biomedical research from T1 through T4. We have provided pathways for our clinicians and our integrated healthcare system to expand implementation science, population health, community-engaged research, and clinical trials while also encouraging basic scientists to innovate new therapeutics and diagnostics. This broad involvement with our community and investigators has allowed the CTSA to impact a wide range of research extending from drug design and improving clinical trials management, to training a new research workforce, and to using implementation science for community-engaged and healthcare research. Indeed, the ICTR’s mission—to advance research across the translational spectrum into clinical practice through its integrated infrastructure, innovative training, and institutional co-investment—has evolved in step with that of the National Center for Advancing Translational Sciences. In this application, we will 1) leverage CTSA resources with institutional assets that support state-of-the-art informatics to accelerate the transfer of discoveries to healthcare via an Evidence Generation Framework, and support regulatory streamlining, innovative analytics, and assist with all phases of C/T research; 2) develop the next generation of research workforce and teams, using novel education, training, mentoring, pilot study support, and career development resources that span translational domains; 3) expand collaborations and engagement, both with the CTSA network and other hubs, and the Bronx community and healthcare partners in an integrative paradigm with strategies developed in collaboration with community partners, investigators, and institutional leadership to improve population health; 4) advance life span, child health, and aging research across genders and special populations, by working with unique platforms for stakeholder-engaged research, patient safety and implementation science, the Montefiore Accountable Care Organization, and the New York City Practice-Based Research Network; and 5) innovate methods and processes that advance C/T sciences, and enhance quality, safety, and efficiency of C/T research. We will integrate the CTSA Trial Innovation Network into our ecosystem of multisite clinical trials, foster innovative methods for biomarker assays and biobanking for precision medicine, and leverage the CTSA Common Metrics Initiative to support our hub’s Evaluation and strategic management. Overall, the Einstein- Montefiore ICTR will fulfill NCATS’s tripartite mission to innovate, educate, and implement.