Core F: Research Education Component (RL5)

研究教育组成部分（REC）计划-摘要 波士顿大学阿尔茨海默病中心（BU ADC）的一个主要研究重点是 脑老化，认知能力下降和创伤性脑损伤（TBI）的长期影响之间的关系。慢性 创伤性脑病（CTE）现在被广泛认为是慢性脑损伤患者进行性痴呆的重要原因。 职业运动员反复遭受轻度TBI。BU ADC致力于培养下一个 在神经退行性疾病（包括CTE）的临床，基础和转化研究方面的领导者。 为此，研究教育部分（REC）将利用BU ADC的独特专业知识， 在BU附属教师提供临床，基础和转化研究的高级培训，因为它涉及到 CTE和神经变性的共同主题，包括基本机制，以及它们的临床， 认知和行为后遗症 区域环境中心的科学和研究培训将侧重于： (1)CTE，包括其病理学、病理生理学、风险因素、遗传学、生物标志物、临床症状和 行为表现，以及 (2)与神经变性相关的共同主题，包括病理学，病理生理学，风险因素， CTE的遗传学、生物标志物、临床症状和行为表现与 其他神经变性疾病，如导致额颞叶痴呆、原发性进行性痴呆、 失语症、皮质基底综合征、路易体痴呆、AD等。 例如，研究主题可以包括比较和对比tau在各种疾病中的作用。 神经退行性疾病，以及其通过大脑的传播作为一个最终的共同途径。其他研究 主题可能包括比较情绪化的病理生理学和行为表现， 与额颞叶变性相比，CTE中的失调。因此，REC将准备 下一代临床医生，研究人员和临床科学家治疗，理解和开发新的 不仅是CTE的治疗，而且是衰老中神经退行性疾病的整个谱。

Research Education Component (REC) Program - Abstract A major research focus of the Boston University Alzheimer's Disease Center (BU ADC) is the intersection between brain aging, cognitive decline, and the long-term effects of Traumatic Brain Injury (TBI). Chronic Traumatic Encephalopathy (CTE) is now widely recognized as a significant cause of progressive dementia in professional athletes who have sustained repeated mild TBI. The BU ADC is committed to training the next generation of leaders in clinical, basic, and translational research in neurodegenerative diseases including CTE. To this end, the Research Education Component (REC) will leverage the unique expertise of the BU ADC and affiliated faculty at BU to provide advanced training in clinical, basic, and translational research as it relates to CTE and to common themes of neurodegeneration including the basic mechanisms, as well as their clinical, cognitive, and behavioral sequelae. The scientific and research training of the REC will be focused on: (1) CTE, including its pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations, and (2) common themes related to neurodegeneration, including how pathology, pathophysiology, risk factors, genetics, biomarkers, clinical symptoms, and behavioral manifestations of CTE compare and contrast to other neurodegenerative diseases such as those that lead to frontotemporal dementia, primary progressive aphasia, corticobasal syndrome, dementia with Lewy bodies, AD, and others. For example, research topics may include comparing and contrasting the role of tau in various neurodegenerative disorders, and its spread through the brain as one final common pathway. Other research topics may include comparing the pathophysiology and behavioral manifestations of the emotional dysregulation in CTE compared to that of the frontotemporal lobar degenerations. The REC will thus prepare the next generation of clinicians, researchers, and clinician-scientists to treat, understand, and develop new therapies not only for CTE but for the entire spectrum of neurodegenerative diseases in aging.