Botswana-UPENN Research Consortium of HPV-related Cervical Cancer in HIV Patients

在这个U54申请中，我们提出了一个跨学科的研究联盟， 博茨瓦纳（UB）和宾夕法尼亚大学（UPenn）。该联盟将专注于多个领域， 与一种癌症类型相关的研究，即HIV血清阳性患者中的HPV相关宫颈癌，以及 通过大力强调辅导和教育，建设博茨瓦纳的研究能力。的 联盟将汇集来自UB和UPenn的经验丰富的调查人员，他们具有指导方面的专业知识， 研究方法学、病毒肿瘤学、癌症治疗学和行为研究。中央研究 该联盟的主题是确定流行病学，发病机制，行为，临床， HIV血清学阳性患者中HPV相关宫颈癌的免疫危险因素和最佳治疗方法 博茨瓦纳的妇女，可转化为有效的预防和治疗战略 这将降低艾滋病毒相关宫颈癌的负担和相关发病率和死亡率。一个 伴随的主要重点将是发展博茨瓦纳的可持续研究基础设施， 指导和教育。这将是一个机会，建立在UB有关独立的研究能力， 艾滋病毒阳性个体的癌症。该联盟将为未来更多的平等奠定基础。 UB和UPenn之间的研究伙伴关系。该联盟将实现其中心目标， 通过研究三种艾滋病毒相关宫颈癌的有效预防和治疗策略 独特的前瞻性队列。研究围绕三个项目和四个支持核心组织。

In this U54 application, we propose an inter-disciplinary research consortium between the University of Botswana (UB) and The University of Pennsylvania (UPenn). The consortium will focus on multiple areas of study related to one cancer type, HPV-associated cervical cancer in HIV seropositive patients as well as building research capacity in Botswana through a strong emphasis on mentoring and education. The Consortium will bring together experienced investigators from UB and UPenn with expertise in mentoring, research methodology, viral oncology, cancer therapeutics, and behavioral studies. The central research theme of the Consortium is to determine the epidemiology, pathogenesis, behavioral, clinical, and immunological risk factors, and optimal therapeutic approaches of HPV-associated cervical cancer in HIV-seropositive women in Botswana which can be translated into effective prevention and treatment strategies that will lower the burden and associated morbidity and mortality of HIV-associated cervical cancer. An accompanying major focus will be on developing sustained research infrastructure in Botswana through mentoring and education. This will be an opportunity to build independent research capacity at UB related to cancer in HIV-positive individuals. This Consortium will lay the groundwork for additional future equal research partnerships between UB and UPenn. The Consortium will achieve its central goal of developing effective prevention and treatment strategies for HIV-associated cervical cancer through the study of three unique prospective cohorts. Research is organized around three projects and four supporting cores.