Core C - Biostatistics Core

摘要 生物统计核心负责向所有项目提供统计支助。核心将领导或协助 参与所有研究数据库的开发，并将领导其统计分析。核心将提供分析 DNA甲基化数据，包括质量控制、数据标准化、软件选择和结果 分析约2,000个DNA样本，并进行表观基因组范围的关联研究 吸烟者与尼古丁和致癌物代谢的生物标志物的关系。核心将提供以下分析 与代谢、DNA损伤和DNA甲基化的生物标记物有关的病例对照数据，并执行 Meta分析，以便包括来自ARIC等外部队列的数据/结果。核心还将提供 通过大量吸烟互动分析种族差异、吸烟差异和民族性 新陈代谢、DNA损伤和修复的生物标志物，使用个人的尿液和/或DNA样本 通过临床核心B招聘，或由项目直接招聘。将执行大多数统计分析 使用现有的R或SAS程序。在某些情况下，可开发新的统计方法(如果已有 统计程序不足以进行分析。

ABSTRACT The Biostatistics Core is responsible for providing statistical support to all projects. The Core will lead or assist in the development of all study databases and will lead their statistical analysis. The Core will provide analysis of DNA methylation data including quality control, data normalization, software selection, and outcome analysis, and perform an epigenome-wide association study of DNA samples from approximately 2,000 smokers in relation to biomarkers of nicotine and carcinogen metabolism. The Core will provide analysis of case-control data in relation to biomarkers of metabolism, DNA-damage, and DNA methylation, and perform meta-analysis in order to include data/results from outside cohorts such as ARIC. The Core will also provide analysis of ethnic differences, smoking differences, and ethnicity by smoking interactions for a large number of biomarkers of metabolism, DNA damage and repair, using urine and or DNA samples from individuals recruited through the Clinical Core B, or by the projects directly. Most statistical analysis will be performed using existing R or SAS procedures. In some cases new statistical methodology may be developed if existing statistical procedures are inadequate for analysis.