Center for Environmental Genetics

总体-项目摘要 环境遗传学中心（CEG）的愿景是成为基因-环境领域的全球领导者 互动（GXE）研究和翻译。它的使命是进行创新的，多学科的GXE研究 并通过社区授权，在国内和地球仪将发现转化为疾病预防。 该中心是GXE研究的先驱。我们在当前的筹资周期中取得了显著进展， 采取新举措，促进对表观遗传学的理解，将其作为遗传学与环境之间的桥梁; 进一步确定易感性窗口;确定复杂疾病早期起源的潜在机制; 并发现遗传变异对疾病易感性的影响。在未来的基金周期，我们将继续 在基于机制的GXE知识和翻译方面取得了长足的进步， 疾病我们乐观的前景是基于我们拥有的宝贵的智力和物质资源 在过去的25年里发展起来的。首先，我们已经建立了十个高度重视的队列，有利于环境 健康科学（EHS）研究在CEG或与其他NIEHS-EHSC中心共享。二是 建立了高通量多组学研究的领先技术和能力。三是 一些最先进的生物信息学方法和数据分析中的现代管道， 更好地理解复杂疾病的机制基础。我们终于有 吸引了令人难以置信的年轻人才准备成为下一代的EHS领导人通过指导由一个 思想领袖在该领域的干部。我们的力量是巨大的，我们的资源是深厚的，我们的凝聚力 支持强大的中心身份。展望新的融资周期，我们未来的目标如下：（1） 从区域群体扩展到国际群体，以进一步研究新出现的环境污染物;（2） 开发新的统计学和生物信息学方法，以确定个体和累积效应， 暴露和化学物质在混合物中的相互作用;（3）将我们的组学平台扩展到单细胞 转录组与表观基因组分析，询问线粒体基因组和表观基因组， 宏基因组学在微生物组学中的应用;（4）实现GXE研究向精确化方向发展的潜力 以医学为基础的风险评估、预防和治疗;（5）最大限度地减少环境疾病， 通过与社区，卫生保健专业人员， 我们的目标是加强我们对健康状况差距很大的弱势群体的关注。我们 这些目标与NIEHS战略计划的11个目标保持一致。我们相信，我们将再次大大 用新的概念和技术为EHS知识基础做出贡献，并发展人力资本 通过训练。我们的努力将最大限度地减少环境暴露对大辛辛那提健康的影响， 在我们的国家和整个地球仪。

OVERALL – Project Summary The vision of the Center for Environmental Genetics (CEG) is to become a global leader in gene-environment interaction (GXE) research and translation. Its mission is to conduct innovative, multidisciplinary GXE research and translate discoveries to disease prevention via community empowerment, at home and around the globe. The Center is a pioneer in GXE research. We have made outstanding progress in the current funding cycle with new initiatives in advancing the understanding of epigenetics as a bridge between genetics and the environment; further defining windows of susceptibility; identifying mechanisms underlying early-origins of complex diseases; and discovering the impact of genetic variants on disease susceptibility. In the coming fund cycle, we will continue on a steep trajectory of progress in mechanism-based GXE knowledge and translation to reduce environment disease. Our optimistic outlook is based on the valuable intellectual and physical Center resources that we have developed over the past 25 years. First, we have built ten highly valued cohorts, conducive to environmental health sciences (EHS) research within the CEG or shared with other NIEHS-EHSC Centers. Second, we have established leading-edge technologies and capabilities in high-throughput multi-omics research. Third, we have some of the most advanced bioinformatics methods and modern pipelines in data analysis to unlock the power of omics for better understanding of the mechanistic basis underlying complex diseases. Finally, we have attracted incredible young talent ready to become the next-generation of EHS leaders through mentoring by a cadre of thought-leaders in the field. Our strength is immense, our resources run deep, and our cohesiveness supports a strong Center identity. Looking to our new funding cycle, we have the following future goals: (1) To expand from regional to international cohorts to further our study of emerging environmental contaminants; (2) To develop novel statistical and bioinformatics methods to identify the individual and cumulative effects of exposures and the interactions of chemicals in a mixture; (3) To extend our omics platform to single-cell transcriptome with epigenome analyses, interrogation of the mitochondrial genome and epigenome and applications of metagenomics to microbiome; (4) To realize the potential of GXE research towards precision medicine-based risk assessment, prevention, and therapies; (5) To minimize environmental disease and promote healthier living in clean environments through partnerships with communities, health care professionals, and policy-makers and to sharpen our focus on vulnerable populations with significant health disparities. Our goals are well-aligned with the eleven goals of the NIEHS Strategic Plan. We believe we again will significantly contribute to the EHS base of knowledge with new concepts and technologies, and develop human capital through training. Our efforts will minimize the impact of environmental exposures on health in Greater Cincinnati, in our nation and across the globe.