COBRE in Stroke Recovery

第二阶段Cobre的总体目标是在以下领域实现卓越的多学科协作研究 从中风中恢复。中风康复研究对南卡罗来纳州尤为重要，因为 全州范围内不成比例的中风发病率导致不必要的经济、社会和个人负担 中风后的残疾。我们的组织理念是，增加对经验依赖的理解 神经可塑性的本质将使我们能够研究和开发固有的神经恢复过程，开发 并翻译出新的基于机制的干预策略，最终提高功能和质量 中风康复者的生活。具体目标是：1)扩大基金的临界质量 研究人员进行中风康复研究；2)加强支持中风的创新科学核心 恢复研究；以及3)推动独立的、可持续的、多学科的持续发展 专题研究计划。合作伙伴关系继续推动中风康复期的科布雷 中心，由一名博士生物医学工程师/生物力学科学家担任项目主任和负责人 研究员，以及一名MD/临床中风专家担任副项目主任，整合资源和 来自两个不同的卫生专业学院的学科，医学院和卫生学院 南卡罗来纳州医科大学的职业。科布雷有四个科学核心：1) 量化行为评估和康复核心提供标准化的经验和量化的 行为和功能的测量。2)脑刺激核心提供了一种可塑性修改佐剂 用于治疗和定量测量可塑性和神经生理学。3)神经影像核心 提供可塑性以及结构和功能连接性的定量测量。4)临床与 翻译工具和资源核心提供访问创新所需的工具和资源的途径 人体研究，包括开发综合多学科数据库(CMD) 与MUSC的CTSA合作，这将是一个支持研究和数据共享的新型研究门户。四 新的初级调查员(JIS)已经竞争性地被选入第二阶段。每个人都在调查一个重要的 在中风恢复方面，使用一套在中风恢复研究环境中很少找到的测量工具。 本科布雷的主要创新特征包括：(A)核心的跨专业、多学科的专门知识 领导者和初级调查人员；(B)整合运动捕捉和临床评估工具、脑刺激 用于中风康复研究的生物统计和数据共享的工具、神经成像工具和资源； 和(C)综合多渠道指导办法，使联检组做好准备，成为#年的未来领导者 卒中康复的临床/翻译研究。广泛的机构支持包括相当灵活的 资金、新教师招聘和核心增强，以确保中心的长期成功和生存能力。

The overall goal of this Phase II COBRE is to enable outstanding multidisciplinary collaborative research in recovery from stroke. Stroke recovery research is especially important to South Carolina, because a disproportionate rate of stroke incidence statewide results in undue economic, social and personal burdens from post-stroke disability. Our organizing concept is that increased understanding of the experience-dependent nature of neural plasticity will allow us to investigate and exploit inherent neural recovery processes, develop and translate novel mechanism-based interventional strategies, and ultimately improve the function and quality of life of individuals recovering from stroke. The specific aims are to: 1) Expand the critical mass of funded investigators conducting stroke recovery research; 2) Strengthen innovative scientific cores that support stroke recovery research; and 3) Advance the ongoing development of an independent, sustainable, multidisciplinary thematic research program. A collaborative partnership continues to drive the COBRE in Stroke Recovery Center, composed of a PhD biomedical engineer/biomechanical scientist as Program Director and Principal Investigator, and an MD/clinical stroke expert as Associate Program Director, coalescing resources and disciplines from two distinct health professional schools, the College of Medicine and the College of Health Professions, at the Medical University of South Carolina. This COBRE has four scientific cores: 1) The Quantitative Behavioral Assessment & Rehabilitation Core provides standardized experience and quantitative measurement of behavior and function. 2) The Brain Stimulation Core provides a plasticity-modifying adjuvant for treatment and quantitative measurement of plasticity and neurophysiology. 3) The Neuroimaging Core provides quantitative measurement of plasticity and structural and functional connectivity. 4) The Clinical & Translational Tools and Resources Core provides access to the tools and resources necessary for innovative research with human subjects, including development of Comprehensive Multidisciplinary Database (CMD) in collaboration with MUSC’s CTSA that will be a novel research portal to support research and data sharing. Four new Junior Investigators (JIs) have been competitively selected for Phase II. Each is investigating an important aspect of stroke recovery using a suite of measurement tools rarely found in stroke recovery research settings. Key innovative features of this COBRE include: (a) the interprofessional, multidisciplinary expertise of the core leaders and Junior Investigators; (b) integration of motion capture and clinical assessment tools, brain stimulation tools, neuroimaging tools, and resources for biostatistics and data sharing applied to stroke recovery research; and (c) a comprehensive multiple source mentoring approach to prepare the JIs as future leaders in clinical/translational research in recovery from stroke. Extensive institutional support includes substantial flexible funds, new faculty recruitment and core enhancements to ensure the Center’s long-term success and viability.!