Maps, models and modifiers of brain changes in psychosis

精神病从根本上改变了一个人与现实的关系。脑部扫描可以绘制出大脑的哪些部分受到精神病的影响，但它们无法识别导致这些变化的细胞过程。我的奖学金旨在通过将脑成像与遗传学和数学建模相结合来解决这一差距，以识别影响精神病风险的脑回路和分子，并开发靶向治疗来修改这些功能失调的回路。

Psychosis fundamentally alters one’s relationship with reality. Brain scans can map which parts of the brain are affected by psychosis, but they cannot identify the cellular processes that cause these changes. My fellowship aims to address this gap by integrating brain imaging with genetics and mathematical modelling to identify the brain circuits and molecules that impact risk for psychosis, and to develop targeted therapies to modify these dysfunctional circuits.