Conduct of studies to evaluate the toxicity phenolic benzotriazoles (PBZTs) in laboratory animals for the National Toxicology Program (NTP)

该项目的目标是为国家毒理学计划(NTP)的危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及在暴露于九个类别成员的两周后对多溴联苯并三氮唑的毒性进行表征。这个项目还将允许在班级成员之间进行比较。目前，关于这类化合物的毒性信息很少，甚至没有。该项目的数据将用于制定关于PBZTS对老鼠的潜在毒性和致癌性的合理、科学的结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众还可以充分了解接触多溴联苯的风险因素。 关键词：毒性、酚类苯并三唑

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the toxicity of PBZTs following two-week exposures to nine class members. This project will also permit comparisons among class members. Currently there is little to no toxicity information on this class of compounds. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of PBZTS in rats and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to PBZTs. Keywords: toxicity, phenolic benzotriazoles