Research Training in Pediatric Infectious Diseases

项目摘要 本修订后的T32奖续期申请自1980年以来一直获得资助，请求支持 在未来五年内每年培训两名学员。耶鲁大学儿科传染病部 由一组严肃的研究者组成，他们进行基于实验室或临床的研究， 转化研究和谁作出了重要贡献，我们的发病机制的理解， 流行病学和预防儿童和成人感染。该司也有着悠久的历史， 选择和培训积极性高的儿科医生从事富有成效的研究工作，其中许多人 在学术医疗中心、政府机构、非政府组织和行业中担任重要领导角色。 这项提案有什么新内容？我们计划：（1）提供正式的高级教学培训， 指导研究，将最终在健康科学硕士学位或博士学位， 研究医学;（2）建立两条正式的研究轨道：临床基础和实验室基础 翻译研究-在任何一个轨道上都有国际研究的机会;（3）增加机会 在低收入和中等收入国家开展全球传染病研究， 耶鲁大学教师导师/培训师和选定的全球导师在牙买加，巴西， （4）通过招募更多的教员导师/培训员，进一步扩大研究员的潜在研究领域 在微生物组、感染界面和免疫系统等重要领域拥有专业知识， （5）扩大T32的申请人范围，以包括博士博士后学员 谁想要沉浸在重大传染病转化研究;（6）提高多样性 通过积极招募在生物医学研究中代表性不足的个人;以及（7）引入新的 领导方案。我们的目标是识别和招募优秀的申请人，帮助他们学习 批判性地思考，并获得研究技能和经验，这将为他们的富有成效的职业生涯做好准备， 全球重大传染病的临床/转化研究，将为以下方面做出真实的贡献： 改善健康。我们描述了一个程序，是为每个学员量身定制，但旨在确保 所有这些都获得了核心竞争力，能够进行高质量的临床/转化研究。基石 该培训计划将包括实验室或临床方面的密切指导和强化培训， 与儿科传染病相关的研究。所需的教学培训将通过 耶鲁大学生物和生物医学科学联合项目提供的研究生课程， 公共卫生学院，国家临床医生学者计划（前罗伯特伍德约翰逊临床 学者计划）和耶鲁大学研究医学计划。所有学员将有个性化的 发展计划和职业指导，医生研究员也将接受临床培训， 获得儿科传染病委员会认证的资格

Project Summary This revised application for renewal of our T32 award, which has been funded since 1980, requests support for two trainees per year in each of the next five years. The Division of Pediatric Infectious Diseases at Yale is composed of a diverse group of serious investigators who conduct laboratory-based or clinically-based translational research and who have made important contributions to our understanding of the pathogenesis, epidemiology, and prevention of infections in both children and adults. The Division also has a long history of selecting and training highly motivated pediatricians for productive careers in research, many of whom have assumed prominent leadership roles in academic medical centers, government agencies, NGOs, and industry. What is new in this proposal? We plan to: (1) Offer formal advanced didactic training in combination with mentored research that will culminate in either a Master of Health Science degree or a PhD degree in Investigative Medicine; (2) Establish two formal research tracks: clinically-based and laboratory-based translational research – with opportunities for international research in either track; (3) Increase opportunities for conducting global infectious diseases research in low and middle income countries through international collaborative research of Yale faculty mentors/trainers and selected global mentors in Jamaica, Brazil, and Ghana; (4) Further expand potential research areas for fellows by enlisting additional faculty mentors/trainers with expertise in important areas such as the microbiome, the interface of infections and the immune system and emerging infectious diseases; (5) Expand the applicant pool for the T32 to include PhD post-doc trainees who want to be immersed in significant translational research in infectious diseases; (6) Enhance diversity through active recruitment of individuals underrepresented in biomedical research; and (7) Introduce new leadership for the program. Our goals are to identify and to recruit outstanding applicants, to help them learn to think critically, and to acquire research skills and experience that will prepare them for productive careers in clinical/translational research in globally significant infectious diseases that will make a real contribution to improving health. We describe a program that is tailored to each individual trainee, yet is designed to assure that all gain core competencies to be able to perform top quality clinical/translational research. The cornerstone of this training program will consist of a closely mentored and intensive training in laboratory- or clinically- based research related to Pediatric Infectious Diseases. Required didactic training will be available through Graduate level courses offered by the Yale Combined Program in the Biological and Biomedical Sciences, the School of Public Health, the National Clinician Scholars Program (formerly the Robert Wood Johnson Clinical Scholars Program), and the Yale Investigative Medicine Program. All trainees will have individualized development plans and career mentoring, and physician fellows will also receive clinical training that will lead to eligibility for board certification in Pediatric Infectious Diseases.