Transplant Surgery Scientist Training Program

项目摘要/摘要 移植有望扭转数百万患有终末期糖尿病的美国人的临床进程。 器官衰竭阶段，包括一些胃肠道(GI)疾病。然而，一些问题限制了 更广泛的移植机会和与终生需要相关的各种并发症 免疫抑制影响移植的长期成功。因此，该计划的长期目标是 移植外科科学家培训计划(TSSTP)旨在培养和支持相互依赖的移植 为改善需要移植的患者的结局而进行的研究。我们将利用科学技术 跨学术领域的生命科学的进步，并将重点放在推进移植上， 直接和间接改善需要胃肠道器官的患者的健康，与 NIDDK。我们将在以下方面培养下一代博士后科学家和临床医生科学家 外科和胃肠医学将推动移植领域的发展，最好是作为团队科学家。这个 TSSTP的具体目标是1)教育学员了解现有障碍的性质，包括 获得移植的机会并降低移植的并发症，以及2)向他们提供关于移植现状的深刻知识 有可能被用来克服这些障碍的艺术工具、方法和科学方法。 临床移植中存在显著的串扰，因此，我们将应用一个培训计划，利用 跨学科专家移植研究的模块化方法(MATRIX)，这是一个支持 相互依存的团队科学和学科间研究的概念。这一培训模式将是 部署在2个独立的培训路径中，包括1)基础和转化性科学研究 西北大学在免疫生物学和生物医学工程领域的移植研究合作 (NUCTRIBE)，以及2)西北大学移植中心内的健康科学和成果研究 成果研究合作计划(NUTORC)，并在我们的第二个供资周期实施这些计划。共有3个 学员将从一个包含多学科合作的定制矩阵中受益，为期两年 辅导。每个项目必须与移植手术有直接的联系，以及每个项目中的固定学科 马基特是一名移植临床医生。这款T32的战术目标是：1)提供津贴支持 实习生；2)提供多层次、跨学科的指导，将移植临床医生-科学家和 非临床医生-拥有最新研究方法的科学家；3)保护受训人员免受临床活动的影响 竞争他们的时间；4)维持一个既提高质量又提高多样性的管理结构 候选者人才库和受训者；5)提供涵盖两者的培训机会 基础/转化科学(NUCTRIBE)到临床/卫生服务和结果研究(NUTORC) 与临床移植的交叉；以及6)继续进行正在进行的评估过程，以确定 项目是否达到其目标和目的。

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases. However, a number of issues limit broader access to transplantation and various complications related to the need for lifetime immunosuppression affect the long-term success of transplantation. Thus, the long-term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support inter-dependent transplant research in order improve outcomes for patients in need of transplantation. We will leverage scientific advances in the life sciences across academic disciplines, and focus these on advancing transplantation, directly and indirectly improving the health of patients in need of GI organs, consistent with the mission of NIDDK. We will train the next generation of postdoctoral scientists (PhDs) and clinician scientists (MDs) in surgery and GI medicine who will advance the field of transplantation, preferably as team scientists. The specific aims of the TSSTP are 1) to educate trainees about the nature of existing barriers both to higher access to, and lower complications from transplantation, and 2) to arm them with a deep knowledge of state-of- the art tools, methodologies, and scientific approaches that can potentially be used to overcome these barriers. Significant `cross-talk' exists in clinical transplantation, thus, we will apply a training program that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX), a model that espouses the concept of inter-dependent team science and research between disciplines. This training model will be deployed across 2 separate training tracks that include 1) basic and translational scientific research within the Northwestern University Collaborative for Transplant Research in Immunobiology and Biomedical Engineering (NUCTRIBE), and 2) health sciences and outcomes research within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC), and implement these in our second funding cycle. A total of 3 trainees will benefit for 2 years each from a customized MATRIX that will incorporate multidisciplinary co- mentoring. Each project must have a direct link to transplantation surgery, and the anchoring discipline in each MATRIX is a transplant clinician. The tactical objectives of this T32 are to: 1) provide stipend support for trainees; 2) provide multi-level, inter-disciplinary mentorship bringing together transplant clinician-scientists and non-clinician-scientists with state-of-the research methodologists; 3) protect trainees from clinical activities that compete for their time; 4) sustain an administrative structure that enhances both the quality and diversity of the candidate pool and trainees; 5) provide training opportunities that span the spectrum from both basic/translational science (NUCTRIBE) to clinical/health services and outcomes research (NUTORC) at their intersection with clinical transplantation; and 6) continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives.