Transplant Surgery Scientist Training Program

移植外科科学家培训计划

• 批准号: 10628809
• 负责人: Richard M Green
• 金额: $ 24.53万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628809
• 关键词: Scientist; Training Programs; Transplantation Surgery

PROJECT SUMMARY/ABSTRACT Transplantation holds the promise of reversing the clinical course for millions of Americans afflicted with end- stage liver disease. However, several issues limit broader access to liver transplantation and better outcomes including an incomplete understanding of liver disease pathogenesis, the need for better therapies and assessment of clinical outcomes, improved donor availability and access to medical care. Therefore, the long- term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support multi- disciplinary, inter-departmental liver transplant-related research that will improve outcomes for patients with end- stage liver diseases. We will leverage scientific advances in the life sciences across many academic disciplines, with a goal of improving the health of pre- and post-transplantation liver patients, consistent with the mission of NIDDK. The TSSTP will train the next generation of surgeons, hepatologists and PhD investigators in a broad range of liver transplantation-related fields. The goals of the program are to educate trainees about the nature of existing barriers that hinder improved access, lower complications, and improve outcomes in liver transplantation; and to train TSSTP trainees with a deep knowledge of state-of-the art tools, methodologies, and scientific approaches that may be used to overcome these barriers. We will apply a team science approach that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX) model which promotes the concept of inter-dependent, multi-disciplinary research. The MATRIX training model builds on the interdisciplinary team science structure within the Comprehensive Transplant Center (CTC) and offers 1) a basic and translational scientific research track within the Northwestern University Collaborative for Transplant Research in Immuno/Hepatobiology and Biomedical Engineering (NUCTRIBE), and 2) outcomes science track within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC). Trainees will benefit from a customized MATRIX that will incorporate multi-disciplinary mentoring from both NUCTRIBE and NUTORC (3-5 TSSTP mentors). Each project must have a link to liver transplantation or hepatology, and enhancing our long-term goal of improving patient care. In order to successfully reach these goals, we seek to: 1) provide inter-disciplinary training and mentorship that brings together clinicians and scientists with state-of- the-art research methodologists; 2) sustain an administrative structure that enhances quality and diversity of the candidate pool and trainees; 3) conduct rigorous and responsible research; 4) optimize mentor and trainee feedback with an ongoing evaluation process to enhance the ability of the program to meet its goals and objectives; and 5) provide training opportunities, including many lectures and seminars, that span NUCTRIBE and NUTORC at their intersection with clinical liver transplantation. This comprehensive, multi-disciplinary approach will allow us to enhance our liver transplantation-related research and train the next generation on physicians and scientists so that we can improve patient care.

项目摘要/摘要 移植有望逆转数百万患有终末期肾病的美国人的临床病程， 肝病分期然而，一些问题限制了更广泛的肝移植和更好的结果 包括对肝病发病机制的不完全理解，需要更好的治疗方法， 评估临床结果，改善捐赠者的可用性和获得医疗服务的机会。因此，长期以来- 移植手术科学家培训计划（TSSTP）的长期目标是培养和支持多个 学科，跨部门的肝移植相关研究，将改善患者的结局， 肝脏疾病分期我们将利用生命科学在许多学科领域的科学进步， 其目标是改善肝移植前后患者的健康状况，与以下使命一致： NIDDK。TSSTP将在广泛的领域培训下一代外科医生，肝病学家和博士研究人员。 肝移植相关领域的范围。该计划的目标是教育学员了解自然 现有障碍阻碍改善肝脏的通路、降低并发症和改善结局 移植;并培训TSSTP学员，深入了解最先进的工具，方法， 可以用来克服这些障碍的科学方法。我们将采用团队科学方法， 利用跨学科专家移植研究的模块化方法（MATRIX）模型， 促进相互依赖的多学科研究的概念。MATRIX培训模型建立在 综合移植中心（CTC）内的跨学科团队科学结构，并提供1）基本的 西北大学移植合作组织（Northwestern University Collaborative for Transplant） 免疫/肝脏生物学和生物医学工程研究（NUCTRIBE），以及2）结果科学轨道 西北大学移植成果研究合作组织（NUTORC）。学员将 受益于定制的MATRIX，该MATRIX将结合NUCTRIBE和 NUTORC（3-5名TSSTP导师）。每个项目必须与肝移植或肝病学有联系， 加强我们改善病人护理的长期目标。为了成功实现这些目标，我们力求： 1)提供跨学科的培训和指导，将临床医生和科学家聚集在一起， 最先进的研究方法学家; 2）维持一个行政结构，提高质量和多样性的 候选人库和学员; 3）进行严格和负责任的研究; 4）优化导师和学员 通过持续的评估过程提供反馈，以提高计划实现其目标的能力， 目标; 5）提供培训机会，包括许多讲座和研讨会，跨越NUCTRIBE 和NUTORC与临床肝移植的交叉点。这一综合性、多学科 这种方法将使我们能够加强我们的肝脏移植相关研究，并培养下一代 医生和科学家，这样我们就可以改善病人的护理。

项目成果

Role of monocytes and macrophages in regulating immune response following lung transplantation.

• DOI: 10.1097/mot.0000000000000313
• 发表时间: 2016-06
• 期刊: Current opinion in organ transplantation
• 影响因子: 2.2
• 作者: Chiu S;Bharat A
• 通讯作者: Bharat A

Detection of medical errors in kidney transplantation: a pilot study comparing proactive clinician debriefings to a hospital-wide incident reporting system.

肾移植中医疗错误的检测：一项试点研究，将主动临床医生汇报与全院事件报告系统进行比较。

• DOI: 10.1016/j.surg.2014.05.013
• 发表时间: 2014
• 期刊: Surgery
• 影响因子: 3.8
• 作者: McElroy,LisaM;Daud,Amna;Lapin,Brittany;Ross,Olivia;Woods,DonnaM;Skaro,AntonI;Holl,JaneL;Ladner,DanielaP
• 通讯作者: Ladner,DanielaP

The answer at our fingertips: Volume status in cirrhosis determined by machine learning and pulse oximeter waveform.

• DOI: 10.14814/phy2.15223
• 发表时间: 2022-03
• 期刊: Physiological reports
• 影响因子: 2.5
• 作者: Mazumder NR;Kazen A;Carek A;Etemadi M;Levitsky J
• 通讯作者: Levitsky J

The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story.

• DOI: 10.1016/j.surg.2009.06.052
• 发表时间: 2009-10
• 期刊: Surgery
• 影响因子: 3.8
• 作者: Skaro AI;Jay CL;Baker TB;Wang E;Pasricha S;Lyuksemburg V;Martin JA;Feinglass JM;Preczewski LB;Abecassis MM
• 通讯作者: Abecassis MM

What patients think doctors know: beliefs about provider knowledge as barriers to safe medication use.

患者认为医生知道什么：对提供者知识的信念是安全用药的障碍。

• DOI: 10.1016/j.pec.2013.06.030
• 发表时间: 2013
• 期刊: Patient education and counseling
• 影响因子: 3.5
• 作者: Serper,Marina;McCarthy,DanielleM;Patzer,RachelE;King,JenniferP;Bailey,StacyC;Smith,SamuelG;Parker,RuthM;Davis,TerryC;Ladner,DanielaP;Wolf,MichaelS
• 通讯作者: Wolf,MichaelS