RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

摘要 核心B：RSV与哮喘合作临床确认、生物标本和数据管理 研究核心 核心B被设计为临床确定和数据管理核心。INSPIRE（婴儿） RSV暴露后肺部感染和哮喘易感性）出生队列成功入组 超过1900名足月健康婴儿，并将在第一次随访期间跟踪他们到大约4岁。 融资周期。该核心将纵向随访延长至6-8岁，此时累积的 哮喘的发病率将被定义，包括生理测试以及额外的生物标本，因此 直接向项目1和项目2提供资源。核心将协调数据，以解决基本问题， 通过科学项目提出的关于RSV致喘菌株对儿童哮喘的因果作用的问题 重点关注病毒株和宿主在哮喘发展中的相互作用途径（项目1），以及 特定RSV株引起哮喘的机制（项目2）。我们的具体目标是：（1） 促进INSPIRE队列的纵向随访，为项目1提供生物标本和数据管理 和2;和2）整合来自以下的临床、生理、免疫、微生物组和病毒测序数据： 合作网站，并提供分析支持，以解决跨项目的研究问题。这一核心 组建了一个由流行病学家、病毒学家、免疫学家、生物统计学家组成的互补研究小组， 在队列保留、生物标本采集和处理以及数据方面经验丰富的研究人员 管理由于细支气管炎和哮喘是最常见、最严重的急性和慢性疾病， 这些疾病给弱势群体造成了不成比例的负担， 这个核心和支持的项目将通过提高我们对RSV的理解产生重大，持久的影响， 介导的哮喘。

ABSTRACT CORE B: RSV to Asthma Cooperative Clinical Ascertainment, Biospecimen, and Data Management Research Core Core B is designed as the clinical ascertainment and data management core. The INSPIRE (Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure) birth cohort successfully enrolled over 1900 term healthy infants and will have followed them to approximately 4 years of age during the first funding cycle. This core extends the longitudinal follow-up to age 6-8 years at which time the cumulative incidence of asthma will be defined, and include physiologic testing as well as additional biospecimens, thus providing resources directly to Projects 1 and 2. The core will coordinate the data to address the fundamental questions about the causal role of asthmagenic strains of RSV on childhood asthma through scientific projects that focus on interactive pathways of the viral strain and host on asthma development (Project 1), and the mechanisms through which specific RSV strains cause asthma (Project 2). Our specific aims are to 1) facilitate longitudinal follow-up of the INSPIRE cohort, with biospecimen and data management for Projects 1 and 2; and 2) integrate clinical, physiological, immunologic, microbiome and viral sequencing data from collaborating sites and provide analytic support to address research questions across projects. This core assembles a complementary research team of epidemiologists, virologists, immunologists, biostatisticians, and research personnel experienced in cohort retention, biospecimen acquisition and processing, and data management. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, this core and supported projects will have major, long-lasting impact by improving our understanding of RSV- mediated asthma.