Neurobiology Summer Course

位于马萨诸塞州伍兹霍尔的海洋生物实验室（MBL）的“神经生物学：机制与高级方法”（又名神经生物学课程）的目标是通过强化和沉浸式的神经生物学培训来增强参与者的传统培训，特别关注健康和神经疾病中控制神经系统功能的细胞和分子机制。该项目是一个综合性的研究型课程，为期八周，从6月中旬到8月初，针对的是在读博士和博士后的学员，以及早期进入神经科学领域的教师。本课程的一个特点是有机会与使用最先进技术的国际公认专家并肩工作。目标是使参与者能够使用最先进和适当的技术进行神经科学研究。该课程的一个新的和独特的方面是关注遗传或环境扰动如何导致神经系统疾病。教师与学员的比例≥1:1，学员将受益于约450小时的现代神经生物学三个关键领域的强化实践教学：功能基因组学、电生理学与神经兴奋性、神经元结构与功能成像。参与者通过在团队研究项目中设计和执行实验，获得科学严谨性的实践经验。他们还接受了定量数据分析、适当统计和准备透明显示结果的数字方面的实践培训。最后，参与者将学习避免无意识的偏见和先进技术中遇到的常见陷阱，以及如何批判性地评估数据。该课程的具体目标是：1)向学生介绍健康和神经系统疾病中神经系统的基础和新兴概念；2)在分析神经元结构和功能的先进技术方面提供动手、多学科的培训；3)传授对神经科学数据集的严格实验设计和定量分析的理解；4)通过建立专业技能和广泛的师徒网络来促进独立性。课程完成后，学员将转变为严谨、无畏、富有创造力的科学家，坚定地致力于国家科学与发展研究所的战略目标，并准备成为未来的领导者。

The goal of “Neurobiology: Mechanisms & Advanced Approaches” (aka the Neurobiology course) at the Marine Biological Laboratory (MBL) in Woods Hole, MA is to augment conventional training of participants with intensive and immersive training in neurobiology with a particular focus on cellular and molecular mechanisms that govern nervous system function in health and neurological disorders. This program is a comprehensive, research-oriented course that runs for eight weeks, from the mid-June to early August and it is targeted to pre- and post-doctoral trainees as well as early-stage faculty members transitioning into neuroscience. A hallmark of this course is the opportunity to work side-by-side with internationally recognized experts using state-of-the- art technologies. The goal is to empower participants to approach neuroscientific inquiry using the most advanced and appropriate technologies available. A new and unique aspect of the course is the focus on how genetic or environmental perturbations lead to neurological disorders. With a faculty to participant ratio of ≥1:1, participants benefit from ~450 hours of intensive, hands-on instruction in three key areas of modern neurobiology: Functional Genomics, Electrophysiology & Neural Excitability, and Imaging Neuronal Structure & Function. Participants gain practical experience in scientific rigor by designing and executing experiments in team-based research projects. They also receive hands-on training in quantitative data analysis, appropriate statistics, and preparing figures that transparently display their results. Finally, participants learn to avoid unconscious bias and common pitfalls encountered with advanced technologies and how to critically evaluate data. The specific aims of the course are: 1) To introduce students to a breadth of foundational and emerging concepts governing the nervous system in health and neurological disorders; 2) To provide hands-on, multidisciplinary training in advanced techniques for analyzing neuronal structure and function; 3) To impart an understanding of rigorous experimental design and quantitative analysis of neuroscience datasets; 4) To promote independence through building professional skills and a broad mentorship network. Upon course completion, participants will be transformed into rigorous, fearless, and creative scientists, firmly committed to the strategic goals of NINDS, and poised to become the leaders of the future.