CardioPulmonary Vascular Biology COBRE

卓越生物医学研究中心(CPVB)的愿景 Cobre)是为了促进对影响肺和心血管的血管疾病的了解 系统。这一愿景将通过一个多学科小组进行研究来实现 使用尖端工具了解血管病理生物学的杰出研究人员 疾病。在第二阶段的申请中，我们寻求将资金续期5年。我们将继续 三个合作机构的研究伙伴关系--海洋国家研究所(OSRI)、罗德岛 岛医院和布朗大学。申请机构OSRI是一家非营利性研究和教育机构 与沃伦·阿尔珀特附属的教学医院普罗维登斯退伍军人医疗中心合作 布朗大学医学院。在第一阶段，CPVB Cobre支持开发一个 研究人员，提供职业发展和研究技能培训，并鼓励新的研究 研究人员、导师和其他教职员工之间的合作。强大的机构支持带来了专家 访问该中心，导致更多的研究合作。的教学和辅导活动 CPVB Cobre调查人员提高了本科生和研究生的血管生物学知识 学生以及博士后实习生和初级教职员工。CPVB Cobre调查人员参加了 在第一阶段成功获得761万美元的研究资金，在第一阶段将使用类似的方法 已经确定了五名优秀的初级调查人员，他们的背景、技能、 和研究兴趣。将使用创新的方法探索新的研究领域，以扩大 Cobre技术资源的范围。因此，CPVB COBRE将继续拓宽范围和深度 罗德岛合伙机构的血管生物学研究。心肺血管 BioCobre为第二阶段的资助提出了以下具体目标：(1)创建一个多学科 研究血管损伤和修复的研究人员小组。(2)提供研究支持、保护时间、 和指导，使初级调查人员能够成为独立的科学家，并为 研究生涯和专业发展。(三)将心肺血管生物中心扩容为 新的研究领域，从而加强和拓宽合作机构的血管生物学研究。 (4)提供支持血管生物学研究的服务，开发自给自足的细胞/器官核心。 这些目标的实现将导致心肺血管生物学的加强和拓宽 科布雷将成为新的跨学科科学合作的基础，对 对肺病和心血管疾病的了解，并改善老年人的健康状况 罗德岛和这个国家。

The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and cardiovascular systems. This vision will be accomplished through research performed by a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases. In this phase II application we seek to renew funding for a second 5 years. We will continue the research partnership of three collaborating institutions—Ocean State Research Institute (OSRI), the Rhode Island Hospital, and Brown University. The applicant institution, OSRI, is the research and education nonprofit associated with the Providence VA Medical Center, a teaching hospital affiliated with the Warren Alpert Medical School of Brown University. In Phase I, the CPVB COBRE supported development of a community of researchers, provided career development and research skill training, and stimulated new research collaborations among the investigators, mentors, and other faculty. Strong institutional support brought expert visitors to the center, resulting in additional research collaborations. Teaching and mentoring activities of CPVB COBRE investigators enhanced knowledge of vascular biology among undergraduate and graduate students, as well as postdoctoral trainees and junior faculty. CPVB COBRE investigators have competed successfully for $7.61 million in research funding during Phase I. Similar approaches will be used during Phase II, and five outstanding junior investigators have been identified who bring complementary backgrounds, skills, and research interests. New areas of research will be pursued using innovative approaches that expand the scope of COBRE technical resources. Thus, the CPVB COBRE will continue to broaden the scope and depth of vascular biology research at the partnering Rhode Island institutions. The CardioPulmonary Vascular Biology COBRE proposes the following specific aims for Phase II of funding: (1) Create a multidisciplinary group of investigators in studies of vascular injury and repair. (2) Provide research support, protected time, and mentoring to enable junior investigators to become independent scientists and provide robust support for research career and professional development. (3) Expand the CardioPulmonary Vascular Biology Center into new research areas and thereby enhance and broaden vascular biology research at collaborating institutions. (4) Provide services supporting vascular biology research and develop a self-sustaining Cell/Organ Core. Accomplishment of these aims will result in a strengthened and broadened CardioPulmonary Vascular Biology COBRE that will be the basis for new interdisciplinary scientific collaborations, significant contributions to understanding of pulmonary and cardiovascular diseases, and improvements in the health of the citizens of Rhode Island and the nation.