Michigan Alzheimer's Disease Core Center

总体来说 摘要 密歇根州阿尔茨海默病核心中心(密歇根州ADCC)旨在培育和加强创新 阿尔茨海默病(AD)和相关痴呆的研究，长期目标是开发有针对性的 这些具有挑战性的疾病的治疗方法。该中心将建立在现有的深层基础设施和研究基础上 在密歇根大学(UM)的痴呆症和衰老研究方面的优势。密歇根州ADCC将 强调寻求识别、理解和调节非β-淀粉样蛋白因子的研究 阿尔茨海默病和其他痴呆症的脑功能障碍和神经变性。这种关注的理由是 虽然最近的研究确定了β-淀粉样蛋白在阿尔茨海默病中的核心作用，但许多潜在的可修改因素 此外，淀粉样蛋白还会导致大脑功能障碍和变性，但人们对此知之甚少。这个 密歇根州ADCC将利用在脑成像、痴呆症风险识别和 披露、神经退行性蛋白病的机制研究，以及预测性大数据分析 实现这一目标。作为一个真正的地区性中心，密歇根ADCC将促进整个密歇根大学的研究 通过与密歇根州立大学的合作，在密歇根州各地的校园 大学和韦恩州立大学，并通过与NIA赞助的其他机构的合作，在全国范围内 广告中心(ADC)和计划。密歇根ADCC有四个目标：1)培养、催化和执行 研究AD和相关神经退行性疾病的最高潜在影响；2)促进区域 努力了解、诊断和治疗阿尔茨海默病及相关痴呆症 外展工作；3)提供广泛的痴呆症保健培训和研究机会 通过创新的教育和指导努力照顾专业人员、科学家和学生；以及4) 与其他ADC、NACC和其他多中心研究工作合作，使该领域更接近 对这一组毁灭性疾病的有效治疗。实现这些目标的成功是有保证的 通过六个核心(行政、临床、数据管理和统计； 神经病理学；外展和招聘；研究教育部分)，并通过Close 与相关项目的合作，包括UM蛋白质折叠疾病倡议，Claude D.Pepper 老年美国人独立中心、尤德尔帕金森氏病研究卓越中心以及 密歇根城市非裔美国人老龄化研究中心的更健康的黑人老年人中心。这些和 其他合作导致了新开发的重点是检测早期认知能力下降 服务不足的人群(底特律的非裔美国人)和新的潜在疾病生物标志物。这个 该中心广泛的初步组织和专家团队确保在收到NIA指定后， 密歇根ADCC将在区域和全国范围内产生立竿见影的影响，加强对 更好地了解和治疗阿尔茨海默病和相关形式的痴呆症。

OVERALL Abstract The Michigan Alzheimer’s Disease Core Center (Michigan ADCC) aims to foster and enhance innovative research in Alzheimer’s disease (AD) and related dementias with a long term goal of developing targeted therapies for these challenging disorders. This center will build on the existing deep infrastructure and research strengths in dementia and aging research at the University of Michigan (UM). The Michigan ADCC will emphasize research that seeks to identify, understand, and modulate the non-ß-amyloid factors that contribute to brain dysfunction and neurodegeneration in AD and other dementias. The rationale for this focus is that while recent advances have defined a central role for ß-amyloid in AD, many potentially modifiable factors beyond ß-amyloid contribute to brain dysfunction and degeneration yet remain poorly understood. The Michigan ADCC will leverage established strengths in brain imaging, dementia risk identification and disclosure, mechanistic studies of neurodegenerative proteinopathies, and predictive Big Data analytics to achieve this objective. A truly regional center, the Michigan ADCC will promote research across the UM campus, throughout the state of Michigan via collaborations with our partner universities Michigan State University and Wayne State University, and across the nation through collaborations with other NIA-sponsored AD Centers (ADCs) and programs. The Michigan ADCC has four goals: 1) Foster, catalyze and perform research of the highest potential impact in AD and related neurodegenerative disorders; 2) Promote regional efforts to understand, diagnose and treat AD and related dementias through collaborative scientific and outreach efforts; 3) Provide a wide range of training and research opportunities in the dementias for health care professionals, scientists, and students through innovative educational and mentoring efforts; and 4) Collaborate with other ADCs, the NACC, and other multi-center research efforts to move the field closer to effective therapies for this group of devastating diseases. Success in achieving these goals will be ensured through the fully integrated activities of six cores (Administrative; Clinical; Data Management and Statistical; Neuropathology; Outreach and Recruitment; and Research Education Component ), and through close collaboration with related programs including the UM Protein Folding Diseases Initiative, Claude D. Pepper Older Americans Independence Center, Udall Center of Excellence for Parkinson’s Disease Research, and Healthier Black Elders Center of the Michigan Center for Urban African American Aging Research. These and other collaborations have led to newly developed emphases on the detection of early cognitive decline in an underserved population (African Americans in Detroit) and on novel potential biomarkers of disease. The Center’s extensive preliminary organization and teams of experts ensure that, upon receiving NIA designation, the Michigan ADCC will have an immediate impact, both regionally and nationally, in enhancing research to better understand and treat AD and related forms of dementia.