Wake Forest Alzheimer's Disease Core Center

总体--项目摘要 这项申请建议在维克森林学校建立一个新的阿尔茨海默病核心中心(ADCC) 医学(WFSOM)为病理生理学研究提供全面的基础设施， AD的预防和治疗。我们的中心将提供创新的资源来审查这些贡献 代谢和血管因素从正常衰老到MCI再到AD和 其他痴呆症，通过跨翻译光谱的协调研究。维克森林是 独一无二的装备，可快速开发高影响力的ADCC，因为它具有：1)深度、跨学科 衰老研究基础；2)代谢和血管因子及其相关专业知识 与认知老化和痴呆症的关系；3)与具有高智商的种族多元化社区的紧密联系 痴呆症和代谢/血管疾病的患病率；以及4)特殊的机构支持。这个 我们主题的理论基础是基于研究表明，新陈代谢和血管紊乱是高度 有助于从正常老化向MCI、AD和其他疾病过渡的普遍的、可修改的因素 痴呆症。为了促进专注于这些因素的创新翻译研究，ADCC将招收 来自现有15年代谢/血管风险和杠杆研究的观察性多民族队列研究 通过添加关键终结点来表征AD和其他痴呆症，从而获得广泛的数据。临床核心 将登记一个单独的队列，与AD患者一起增加代谢/血管风险。这个 ADCC将把重点放在非洲裔美国人(AA)和其他服务不足的群体，他们有两倍于 患上阿尔茨海默病，糖尿病和血管疾病的发生率很高。将提供专门的资源 ADCC研究人员，包括用于翻译研究的非人灵长类(NHP)模型。一个储存库 人类和NHP生物标本、遗传/表观遗传学数据和广泛的临床数据将可用于 NACC、NCRAD和其他调查人员。ADCC还将作为一种资源，提供广泛的 广告计划。我们的具体目标是：1)建立全面的综合研究基础设施 专注于从正常老化到MCI、AD和其他痴呆的相变，并提供特殊的 加快代谢和血管因子研究的资源；2)优化AA的参与 成年人更好地了解其AD和痴呆症风险增加的潜在原因；3)扩大 与全国ADCC网络和NACC和NCRAD等主要附属机构的关系；4)提供 对新调查人员进行翻译研究培训，以及关于AD和痴呆症的教育 专业人士、患者和家属以及社区。代谢和血管风险的盛行率 因素，它们对AD表达的重要性，维克森林科学界在这些方面的优势 研究领域，以及我们杰出的机构承诺是NIH资金将 成功地利用这一机会建立了一个ADCC，将对该领域作出重大贡献。

Overall – Project Summary This application proposes a new Alzheimer's Disease Core Center (ADCC) at Wake Forest School of Medicine (WFSOM) to provide a comprehensive infrastructure for research on the pathophysiology, prevention, and treatment of AD. Our Center will provide innovative resources to examine the contributions of metabolic and vascular factors to early phase transitions from normal aging to MCI and then to AD and other dementias, through coordinated research spanning the translational spectrum. Wake Forest is uniquely equipped to rapidly develop a high-impact ADCC because it has: 1) a deep, interdisciplinary foundation in aging research; 2) specialized expertise in metabolic and vascular factors and their relationship to cognitive aging and dementia; 3) strong ties to an ethnically diverse community with high prevalence of dementia and metabolic/vascular disorders; and 4) exceptional institutional support. The rationale for our theme is based on research showing that metabolic and vascular disorders are highly prevalent, modifiable factors that contribute to the transitions from normal aging to MCI, AD, and other dementias. To promote innovative translational research focused on these factors, the ADCC will enroll an observational multi-ethnic cohort from an existing 15-year study of metabolic/vascular risk, and leverage their extensive data by adding key endpoints to characterize AD and other dementias. The Clinical Core will enroll a separate cohort enriched for metabolic/vascular risk, along with participants with AD. The ADCC will focus on African-American (AA) and other underserved groups who are twice as likely to develop AD, and have high rates of diabetes and vascular disease. Specialized resources will be available to ADCC investigators, including non-human primate (NHP) models for translational research. A repository of human and NHP biospecimens, genetic/epigenetic data, and extensive clinical data will be available to NACC, NCRAD, and other investigators. The ADCC will also serve as a resource for a broad spectrum of AD initiatives. Our Specific Aims are to: 1) Establish a comprehensive integrated research infrastructure focused on phase transitions from normal aging to MCI, AD, and other dementias, and provide special resources to accelerate research on metabolic and vascular factors; 2) Optimize the participation of AA adults to better understand the causes underlying their increased risk of AD and dementia; 3) Expand relationships with the national ADCC network and key affiliates such as NACC and NCRAD; 4) Provide training in translational research to new investigators, and education regarding AD and dementia to professionals, patients and families, and the community. The prevalence of metabolic and vascular risk factors, their importance to AD expression, the strengths of the Wake Forest scientific community in these research areas, and our outstanding institutional commitment are indicators that NIH funding will be successfully leveraged to establish an ADCC that will make high-impact contributions to the field.