Regenerative Musculoskeletal Medicine Training Program

 描述（由申请人提供）：在过去的五年中，我们已经建立了一个框架，专注于再生医学领域的培训计划，因为它涉及到肌肉骨骼疾病。我们创建了一个跨学科的肌肉骨骼再生医学团队的计划，由i）培训教师，ii））临床/外科教师导师和iii）实习生组成。研究的重点是一组不同但相互关联的项目，这些项目考虑用细胞重建受损或缺失的肌肉骨骼组织， 支架和生物活性分子，通过：1）应用发育生物学的发现来治疗儿科疾病，ii）开发和使用生物信息学技术来发现新的治疗可能性，iii）对抗同种异体组织移植排斥反应的策略。在这次更新申请中，我们建议将我们的项目范围从目前的四个博士后实习生职位扩大到五个博士后实习生，其中一个是 留给骨科博士后的我们将继续把培养重点放在博士上。和医学博士打算从事跨学科的再生恢复医学。第一个主要目标将是为学员提供以下方面的组合技能：1）干细胞和发育生物学; 2）分子遗传学; 3）组织工程和材料科学; 4）高通量，大规模计算科学的最新技术;和5）临床转化医学，可以在这些领域之一的本科和研究生培训之上分层。第二个主要目标将是教育学员在再生医学的综合方法与实践项目为导向的教学如何i）建立，ii）操作和iii）修改同事的多学科TEM。我们目前的业绩记录表明，这种团队方法使我们的学员能够获得全面的临床经验，这是在“真实的世界”中实现生物工程治疗所需的。这种转化研究结构目前得到了教学课程和研讨会系列的强大集合的支持，旨在介绍和完善博士后学员所需的技能，以理解，设计，撰写，承担和获得再生医学研究项目的校外财政支持。除了致力于为外科医生科学家提供基础研究的培训外，在这次更新中，将更多地关注博士学位的暴露。通过参加大查房和参加/观察受训者的临床教师导师的临床活动，使受训者能够应对高度相关的临床挑战。T32研究和教学培训计划 旨在为个别学员提供两年的资金，为他们的过渡做准备。 更专业的培训和其他支持来源。

 DESCRIPTION (provided by applicant): Over the past five years, we have established a framework for a training program focused on the field of regenerative medicine, as it relates to musculoskeletal disease. We created a program of interdisciplinary musculoskeletal regenerative medicine teams composed of i) a training faculty, ii)) a clinical/surgeon faculty mentor and iii) a trainee. Investigational focus has been on a diverse but interrelated group of projects that consider the reconstitution of injured or missing musculoskeletal tissues with cells, scaffolds and bioactive molecules through: 1) application of findings from developmental biology to treat pediatric disorders, ii) the development and use of bioinformatics technologies to uncover new therapeutic possibilities and iii) strategies to combat the rejection of allogeneic tissue transplants. In this renewal application, we propose to expand our program from its current scope of four postdoctoral trainee positions to five postdoctoral trainees, one of which is reserved for an orthopaedic surgery postdoctoral fellow. We will continue to focus training efforts on Ph.D.'s and M.D.'s intent on a career in interdisciplinary academic regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in: 1) stem cell and developmental biology; 2) molecular genetics; 3) tissue engineering and materials science; 4) state-of the-art technologies in high-throughput, large scale computational science; and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i) build, ii) operate in and iii) modify a multidisciplinary tem of colleagues. Our current track record indicates that this team approach has enabled our trainees to receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure is currently supported by a robust collection of didactic curricula and seminar series designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. In addition to dedication to providing training to surgeon scientists in basic research, in this renewal increased focus will be placed on exposure of Ph.D. trainees to highly relevant clinical challenges through attendance at grand rounds and attendance/observation of the clinical activities of the trainee's clinical faculty mentor. The T32 research and didactic training program is designed to provide individual trainees two years of funding in preparation for their transition into more specialized training and alternative sources of support.