National Consortium on Alcohol and Neurodevelopment in Adolescence: OHSU

项目总结 在青壮年，饮酒量急剧增加，狂欢程度的饮酒量在22岁和 据报道，近一半的人酗酒2。长期频繁酗酒 持续到25岁左右的神经成熟可能会产生比类似的更大的大脑和认知效果 成年后饮酒。响应RFA-AA-17-003，本申请提出了一个研究项目 青少年酒精与神经发育第二阶段全国联合会所在地(NCANDA-2) 确定青春期和青春期大量饮酒的预测因素和影响。 为了实现这一目标，NCANDA-2的OHSU站点将继续遵循150个波特兰地区(n=831)的队列 所有5个站点)参与者(首次访问的基线年龄为12-21岁)，以获取必要的数据以推进我们的 了解青春期发育和青春期饮酒对成人大脑的影响。 NCANDA-2将使用多模式神经成像、认知测试、行为评估、生物扫描 收集，和生态瞬时评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟，参与了 心理调节，对奖励做出反应，似乎很容易受到酒精的神经毒性影响。在……里面 此外，OHSU网站将与杜克大学和USCD网站合作，研究这些项目的恢复 异常现象。具体地说，我们将检查与大量饮酒相关的神经认知的定向程度 大脑完整性缺陷缓解了超过4周的受监测的禁欲。发育中的性别差异， 酒精使用模式，酒精使用对大脑的影响，以及性别差异的心理社会因素(例如， 抑郁症状)将在分析中考虑。使用由此提供的附加纵向数据 更新，我们将确定酒精暴露对青少年发展轨迹的影响 人类大脑，并识别先前存在的心理生物脆弱性，这些脆弱性可能会使青少年或年轻人 酒精使用障碍风险较高的成年人。

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use2. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the OHSU site of NCANDA-2 will continue to follow a cohort of 150 Portland-area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and ecological momentary assessment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the OHSU site will collaborate with the Duke and USCD sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. Sex differences in development, alcohol use patterns, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder.