NCANDA Research Project Site: PITT

项目总结 在青壮年，饮酒量急剧增加，狂欢程度的饮酒量在22岁和 据报道，近一半的人酗酒。长期频繁酗酒 持续到25岁左右的神经成熟可能会产生比类似的更大的大脑和认知效果 成年后饮酒。响应RFA-AA-17-003，本申请提出了一个研究项目 青少年酒精与神经发育第二阶段全国联合会所在地(NCANDA-2) 确定青春期和青春期大量饮酒的预测因素和影响。要实现 这一次，NCANDA-2的匹兹堡地点将继续跟随125个匹兹堡地区(n=831)的队列 5个站点)参与者(基线首次访问的年龄为12-21岁)，以获取必要的数据以推进我们的 了解青春期发育和青春期饮酒对成人大脑的影响。 NCANDA-2将使用多模式神经成像、认知测试、行为评估、生物扫描 收集，和生态瞬时评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟，参与了 心理调节，对奖励做出反应，似乎很容易受到酒精的神经毒性影响。在……里面 此外，匹兹堡网站将与SRI网站合作，研究与睡眠相关的预测因素和 青少年中的一小部分人饮酒。匹兹堡还将与杜克大学的网站合作，收集 奖励反眼跳功能磁共振任务，以评估奖励和认知控制系统的变化 与酒精使用的关系。发育的性别差异、饮酒方式、饮酒对老年人的影响 在分析中将考虑大脑和性别差异的心理社会因素(例如抑郁症状)。 根据这次更新提供的其他纵向数据，我们将确定酒精暴露的影响 关于青春期人脑的发展轨迹，并确定先前存在的心理生物学 这种脆弱性可能会使青少年或年轻人患酒精使用障碍的风险增加。

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy alcohol use in adolescence and young adulthood. To achieve this, the Pittsburgh site of NCANDA-2 will continue to follow a cohort of 125 Pittsburgh-area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and ecological momentary assessment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the Pittsburgh site will collaborate with the SRI sites to study sleep-related predictors and effects of alcohol use in a subgroup of adolescents. Pittsburgh will also collaborate with the Duke site to collect the Rewarded Antisaccade fMRI task to evaluate changes in the reward and cognitive control systems in relationship to alcohol use. Sex differences in development, alcohol use patterns, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder.