Mechanism of Bacterial Resistance to Antimicrobial Peptides

细菌对抗生素的耐药性继续出现并加剧。虽然抗菌肽(AMPs)是目前抗生素的一种有前途的替代品，但细菌也通过改变细胞膜来进化出对它们的耐药性机制。该应用程序将应用一系列分析和生物物理工具来了解细菌如何改变其细胞壁以响应AMP。这一结果将使我们能够设计新的联合疗法来治疗细菌感染。

Bacterial resistance to antibiotics continues to emerge and intensify. While antimicrobial peptides (AMPs) are a promising alternative to current antibiotics, bacteria have also evolved resistance mechanisms to them through changes in their cell membrane. This application will apply a range of analytical and biophysical tools to understand how bacteria change their cell walls in response to AMPs. The results will allow us to design new combination therapies to treat bacterial infections.