CardioPulmonary Vascular Biology COBRE

肺血管生物学卓越生物医学研究中心（CPVB COBRE）是为了提高对影响肺和心血管的血管疾病的认识 系统.这一愿景将通过一个多学科小组的研究来实现， 杰出的研究者，他们使用尖端工具来了解血管病变的病理生物学， 疾病在第二阶段的申请中，我们寻求延长第二个5年的资助。我们将继续 三个合作机构的研究伙伴关系-海洋国家研究所（OSRI），罗得岛 岛医院和布朗大学申请机构OSRI是研究和教育非营利组织 与普罗维登斯VA医疗中心，一个教学医院附属于沃伦阿尔珀特 布朗大学医学院。在第一阶段，CPVB COBRE支持开发一个社区， 研究人员，提供职业发展和研究技能培训，并鼓励新的研究 研究人员、导师和其他教职员工之间的合作。强大的机构支持带来了专家 该中心的访客，导致额外的研究合作。教学和辅导活动 CPVB COBRE研究人员提高了本科生和研究生的血管生物学知识 学生，以及博士后学员和初级教师。CPVB COBRE调查人员参加了 在第一阶段成功获得761万美元的研究经费。在阶段期间将使用类似的方法 二，和五个优秀的初级调查员已确定谁带来互补的背景，技能， 和研究兴趣。新的研究领域将采用创新的方法， COBRE技术资源的范围。因此，CPVB COBRE将继续拓宽范围和深度， 在合作的罗得岛机构进行血管生物学研究。肺动脉 COBRE为第二阶段的资助提出了以下具体目标：（1）建立一个多学科的 血管损伤和修复研究的研究小组。(2)提供研究支持，保护时间， 和指导，使初级研究人员成为独立的科学家，并提供强有力的支持， 研究生涯和专业发展。(3)将肺血管生物学中心扩建为 新的研究领域，从而加强和扩大合作机构的血管生物学研究。 (4)提供支持血管生物学研究的服务，并开发自我维持的细胞/器官核心。 这些目标的实现将导致肺血管生物学的加强和扩大 COBRE将成为新的跨学科科学合作的基础， 提高对肺和心血管疾病的认识，改善 罗得岛和全国。

The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and cardiovascular systems. This vision will be accomplished through research performed by a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases. In this phase II application we seek to renew funding for a second 5 years. We will continue the research partnership of three collaborating institutions—Ocean State Research Institute (OSRI), the Rhode Island Hospital, and Brown University. The applicant institution, OSRI, is the research and education nonprofit associated with the Providence VA Medical Center, a teaching hospital affiliated with the Warren Alpert Medical School of Brown University. In Phase I, the CPVB COBRE supported development of a community of researchers, provided career development and research skill training, and stimulated new research collaborations among the investigators, mentors, and other faculty. Strong institutional support brought expert visitors to the center, resulting in additional research collaborations. Teaching and mentoring activities of CPVB COBRE investigators enhanced knowledge of vascular biology among undergraduate and graduate students, as well as postdoctoral trainees and junior faculty. CPVB COBRE investigators have competed successfully for $7.61 million in research funding during Phase I. Similar approaches will be used during Phase II, and five outstanding junior investigators have been identified who bring complementary backgrounds, skills, and research interests. New areas of research will be pursued using innovative approaches that expand the scope of COBRE technical resources. Thus, the CPVB COBRE will continue to broaden the scope and depth of vascular biology research at the partnering Rhode Island institutions. The CardioPulmonary Vascular Biology COBRE proposes the following specific aims for Phase II of funding: (1) Create a multidisciplinary group of investigators in studies of vascular injury and repair. (2) Provide research support, protected time, and mentoring to enable junior investigators to become independent scientists and provide robust support for research career and professional development. (3) Expand the CardioPulmonary Vascular Biology Center into new research areas and thereby enhance and broaden vascular biology research at collaborating institutions. (4) Provide services supporting vascular biology research and develop a self-sustaining Cell/Organ Core. Accomplishment of these aims will result in a strengthened and broadened CardioPulmonary Vascular Biology COBRE that will be the basis for new interdisciplinary scientific collaborations, significant contributions to understanding of pulmonary and cardiovascular diseases, and improvements in the health of the citizens of Rhode Island and the nation.