Cancer Prevention and Control Research Program

项目摘要/摘要 马基癌症中心(MCC)癌症预防和控制(CP)研究计划高度团结 人口研究和社区癌症控制领域的优势互补 研究的首要目标是减少肯塔基州的癌症差异，重点是该州的 阿巴拉契亚和农村人口。肯塔基州的总体癌症发病率和死亡率最高。 在全美50个州中。令人震惊的是，阿巴拉契亚肯塔基州的癌症发病率和死亡率是 远高于该州非阿巴拉契亚地区的通胀率。这些高利率是由各种因素推动的 潜在因素包括低社会经济地位，低教育程度，高风险行为， 文化障碍和环境暴露。CP计划的优势包括专注于以下方面的研究 揭示环境暴露在肯塔基州高癌症发病率中所起的作用，测试 应对独特文化障碍的干预计划，以及戒烟政策的制定 首创精神。CP方案成员也是制定以人口为基础的方法和 促进项目间癌症研究的措施。CP计划结合了这些优势，以 处理3个主题领域：确定下列社会、文化、行为、遗传和环境因素 有助于提高癌症发病率和死亡率(主题1)；设计、测试、实施和 针对已确定的危险因素(障碍)和减轻癌症负担的干预策略的评估 (主题2)；制定以人口为基础的方法和措施，以促进方案间 癌症研究旨在更准确地确定治疗模式和生物标记物的分布 人口(主题3)。最近，CP项目招募了2名由国家癌症研究所资助的癌症患者 分子流行病学家以其独特的研究资源为基础。目前由28人组成的CP队抽签 来自肯塔基大学的5个学院和12个系，从而促进了积极的跨学科 翻译研究。CP生产率反映在每年与癌症相关的外部资金总额超过 970万美元(每年直接费用670万美元)和本供资期间的245份出版物，其中30份(12%) 是方案间的，83(34%)是方案内的，162(66%)是机构间的。CP研究 涵盖癌症控制的所有环节：预防、早期发现、治疗和 生存能力。CP研究涉及许多癌症部位，包括那些不成比例地导致 肯塔基州的癌症负担很高(即肺癌、结肠癌、乳腺癌和宫颈癌)。因此，CP程序是完整的 为实现减少英联邦癌症发病率和死亡率的总体MCC使命做出贡献。

PROJECT SUMMARY/ABSTRACT Markey Cancer Center's (MCC) Cancer Prevention and Control (CP) Research Program unites highly complementary strengths in the areas of population-based research and community-based cancer control research with the overarching goal of reducing cancer disparities in Kentucky with an emphasis on the state's Appalachian and rural populations. Kentucky has the highest overall cancer incidence and mortality rates among all 50 United States. Alarmingly, the cancer incidence and mortality rates in Appalachian Kentucky are far higher than the rates for the non-Appalachian area of the state. These elevated rates are driven by a variety of underlying factors including low socioeconomic status, low educational attainment, high risk behaviors, cultural barriers, and environmental exposures. Strengths of the CP program include studies focused on uncovering the role environmental exposures play in Kentucky's high cancer incidence rates, testing intervention programs that address unique cultural barriers, and smoking cessation policy development initiatives. CP program members are also national leaders in developing population-based methods and measures that facilitate inter-programmatic cancer research. The CP program combines these strengths to address 3 thematic areas: identification of social, cultural, behavioral, genetic and environmental factors that contribute to the elevated cancer incidence and mortality rates (Theme 1); design, testing, implementation and evaluation of intervention strategies that address identified risk factors (barriers) and reduce the cancer burden (Theme 2); and development of population-based methods and measures that facilitate inter-programmatic cancer research directed at more precisely identifying the distribution of treatment patterns and biomarkers in the population (Theme 3). Most recently, the CP program recruited 2 National Cancer Institute-funded cancer molecular epidemiologists to build on its unique research resources. The current 28-member CP team draws from 5 colleges and 12 departments at the University of Kentucky, thus promoting active interdisciplinary translational research. CP productivity is reflected by total annual external cancer-related funding of over $9.7M ($6.7M annual direct costs) and 245 total publications in the current funding period, 30 (12%) of which are inter-programmatic, 83 (34%) intra-programmatic and 162 (66%) inter-institutional. CP research encompasses all segments of the cancer control continuum: prevention, early detection, treatment and survivorship. CP studies address a number of cancer sites including those that disproportionately contribute to Kentucky's high cancer burden (i.e. lung, colon, breast and cervical cancers). Thus, the CP program is integral to achieving the overall MCC mission to reduce cancer morbidity and mortality in the Commonwealth.