University of Michigan O'Brien Kidney Translational Core Center

摘要-中心概述 为了快速开发有效的治疗方法来预防或逆转慢性肾脏疾病的进展， (CKD)，密歇根大学奥布莱恩肾脏翻译核心中心将支持全谱 一个翻译管道，为我们的机构和机构中的基础和临床研究人员提供资源， 国际研究基地采用三管齐下的方法： 我们独特的CKD队列的扩展，结合其纵向组织，尿液和血清 生物银行，让我们的研究基地的调查人员调查分子原因， 慢性肾脏疾病的终点; 传播和支持最现代和最强大的系统生物学方法， 研究基地的研究人员，以帮助他们有效地确定新的和强大的生物标志物， CKD诊断和治疗的终点和目标; 为我们的研究基地研究者进行队列和系统数据的专家分析和整合 通过使用先进的生物信息学和数据库集成， 识别个体或受试者群体治疗的特定途径和靶点 关于CKD 该中心的目标是： 1)扩展肾脏疾病研究的转化和系统生物学方法， 通过临床试验扩大中心的CKD深度临床表型和生物库工作， 表型和资源生物库核心（C-PROBE）; 2)介绍，刺激和应用最先进的系统生物学方法治疗肾脏疾病 我们的机构研究核心调查人员通过使用先进的 但用户友好的遗传学，转录组学，蛋白质组学，代谢组学和脂质组学方法 通过应用系统生物学核心; 3)增强对复杂肾脏疾病和多标量数据集的理解， 伴随系统生物学方法，以了解其对肾脏的功能影响 通过数据分析确定疾病发展、诊断、进展和治疗潜力 服务核心（DASC）; 4)通过Nephroseq和transSMART扩大全球推广工作; 5)利用肾脏教育丰富计划和试点和可行性计划， 学生和教师进入肾脏研究，并支持我们的研究基地，在他们正在进行的肾脏 research.

ABSTRACT – CENTER OVERVIEW In order to rapidly develop effective therapies to prevent or reverse progression of chronic kidney disease (CKD), the University of Michigan O'Brien Kidney Translational Core Center will support the full spectrum of a translational pipeline providing resources to basic and clinical investigators in our Institutional and International Research Bases using a 3-pronged approach:  Expansion of our unique CKD cohort combined with its longitudinal tissue, urine and serum biobanks to allow our research base investigators to investigate the molecular causes and endpoints of chronic kidney diseases;  Dissemination and support of the most modern and powerful systems biological approaches for research base investigators to help them effectively identify novel and robust biomarkers, endpoints and targets for diagnosis and treatment of CKD;  Expert analysis and integration of cohort and systems data for our research base investigators through the use of sophisticated bioinformatics and database integration that promote identification of specific pathways and targets for treatments for individuals or groups of subjects with CKD. The Center's aims are to: 1) Expand translational and systems biological approaches to kidney disease research by expanding the Center's CKD deep clinical phenotyping and biobanking efforts through the Clinical Phenotyping and Resource Biobank Core (C-PROBE); 2) Introduce, stimulate and apply state-of-the-art systems biological approaches to kidney disease research studies by our Institutional Research Core investigators through the use of sophisticated but user-friendly genetic, transcriptomic, proteomic, metabolomic and lipidomic approaches through the Applied Systems Biology Core; 3) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems biological approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential through the Data Analytic Services Core (DASC); 4) Expand worldwide outreach efforts via Nephroseq and tranSMART; 5) Use the Kidney Educational Enrichment Programs and the Pilot and Feasibility Program to entice trainees and faculty into kidney research and support our research bases in their ongoing kidney research.