AFRICAN FEMALE BREAST CANCER EPIDERMIOLOGY (AFBRECANE) STUDY

非洲女性乳腺癌流行病学研究 项目摘要 乳腺癌是全球女性最常见的癌症，它越来越多地超过宫颈癌， 低收入和中等收入国家（LMIC）最常见的女性癌症。乳腺癌的发病率 2014年，尼日利亚为54.3/100，000（每年24，750例新病例），比2014年的20/100，000有所上升。 1970年代为100，000例（每年新增3，000例）。它现在是尼日利亚妇女的主要癌症负担。那里 是关于非洲妇女乳腺癌的流行病学和分子亚型的争议， 对乳腺癌的发病率和这种发病率的决定因素，如 不同的风险因素;乳腺癌分子亚型的发生率和患病率以及 非洲土著饮食与乳腺癌发病率的关系。在缺乏前瞻性队列研究的情况下， 创新的研究设计和分析技术，使用基于人群的癌症登记数据 （PBCR）研究与乳腺癌发病和分子亚型相关的流行病学因素。 也从未有过乳腺癌的全基因组关联研究（GWAS）， 非洲土著妇女乳腺癌的分子亚型。 虽然许多研究人员认为非洲饮食与乳腺癌风险降低有关， 很少有系统的研究。我们使用我们以前开发的营养流行病学工具 并被验证用于研究非洲妇女的饮食摄入量和乳腺癌风险。我们特别关注 维生素D的作用，并利用营养流行病学和 基因组学流行病学工具。

African Female Breast Cancer Epidemiology (AFBRECANE) Study Project summary Breast cancer is the commonest cancer in women globally and it is increasingly overtaking cervical cancer as the commonest female cancer in low and middle income countries (LMIC). The incidence of breast cancer Nigeria was 54.3 per 100,000 per year (24,750 new cases per year) in 2014 representing a rise from 20 per 100,000 in the 1970s (3,000 new cases per year). It is now a major cancer burden in Nigerian women. There are controversies about the epidemiology and molecular subtypes of breast cancer in African women including limited knowledge about the incidence of breast cancer and determinants of this incidence such as the role of different risk factors; incidence and prevalence of molecular subtypes of breast cancer and the contributions of indigenous African diets to breast cancer incidence. In the absence of prospective cohort studies, we engage innovative research design and analytic techniques to use data from population based cancer registries (PBCR) to study the epidemiological factors associated with incident breast cancer and molecular subtypes. There has also never been a genome wide association study (GWAS) of breast cancer in general and of molecular subtypes of breast cancer in indigenous African women. While many researchers suggest that African diets are associated with reduced risks of breast cancer, there have been very few systematic studies. We use the nutrition epidemiology tools that we previously developed and validated to study dietary intakes and breast cancer risk in African women. We focus in particular on the role of vitamin D and explore potential associations with breast cancer using nutrition epidemiology and genomics epidemiology tools.