Integrated Health Sciences Facility Core

项目摘要 西奈山的早期环境暴露跨学科中心成立于2014年， 使命是促进跨学科的环境健康研究贯穿整个生命过程。集成 健康科学设施核心通过提供以下服务来实现我们这一使命的几个关键组成部分： 环境暴露的测量，影响的分子生物标志物，甚至人类研究人群， 中心成员可以在其环境健康研究中利用这些信息。IHSFC将继续促进 环境健康科学的研究，包括新兴的概念和技术，如混合物， “麻烦”和基于卫星的空气污染遥感（本赠款周期的新服务）。IHSFC 鼓励研究超越孤立地评估化学毒性的还原主义研究， 考虑环境的整体性、暴露的背景（营养/社会环境或性别）和 这些因素之间复杂的相互作用最终预测我们的健康。根据中心的 研究跨学科环境健康的使命，IHSFC作为一个门户，各种 在一个单一的行政保护伞下的专业知识和资源。这种结构提供了一个智力环境， 促进合作，因为IHSFC是中心的跨学科“心脏”，并作为一个 中心枢纽，中心成员可以通过该枢纽访问多个服务场所，从咨询到 化学品的毒理学性质，收集和测量标准和新的咨询 暴露生物标志物，测量效应的分子生物标志物，以及访问现有队列 临床人群。我们的使命是帮助调查人员建立合作者团队， 扩大环境健康科学的范围。为了实现这一目标，IHSFC还开发了切割技术， 为中心成员提供边缘环境测量和生物反应分析，例如我们的高度 基于牙齿的金属暴露的成功生物标志物，其重建过去的暴露剂量和暴露 时机这种生物标志物在我们最近的NIH资助成功中发挥了关键作用，在2个成功的R 01中得到了体现， 一项K奖和两项欧共体人道处的同期赠款。在下一个资助周期，我们将继续发展更多 创新的方法，全面衡量暴露于环境的侮辱，促进获得研究 人口和生物标本档案，并指导研究人员在西奈山现有的核心服务。 IHSFC不复制其他西奈山核心实验室提供的服务。相反，我们利用和 补充其他核心，如我们的临床转化科学奖（CTSA）资助的核心，并促进 获得CTSA核心实验室检测。总的来说，西奈山P30核心中心的IHSFC是一个关键的 资源，使研究人员能够建立高效和协作的团队，可以解决的作用， 环境对生命健康的影响。

Project Summary Mount Sinai's Transdisciplinary Center on Early Environmental Exposures was established in 2014 with the mission to promote transdisciplinary environmental health research across the life course. The Integrated Health Sciences Facility Core fulfills several critical components of our this mission by providing access to measures of environmental exposure, molecular biomarkers of effect and even human study populations that can be leveraged by Center Members in their Environmental health research. The IHSFC will continue to foster studies of environmental health sciences that embrace emerging concepts and technologies, such as mixtures, the “exposome” and satellite-based remote sensing of air pollution (a new service this grant cycle). The IHSFC encourages research that moves beyond reductionist studies assessing chemical toxicity in isolation to consider the totality of the environment, the context of exposure (nutrition/social environment or sex) and the complex interactions among these factors that ultimately predict our health. In keeping with the Center's mission to study transdisciplinary environmental health, the IHSFC serves as a gateway to a variety of expertise and resources under a single administrative umbrella. This structure provides an intellectual milieu that promotes collaboration, as the IHSFC is the transdisciplinary “heart” of the Center and functions as a central hub through which Center Members have access to multiple venues of service, from consultation on toxicologic properties of chemicals, to consultation on collection and measurement of standard and novel exposure biomarkers, to measurement of molecular biomarkers of effect, and to accessing existing cohorts and clinical populations. Our mission is to help investigators establish teams of collaborators who, together, will extend the boundaries of environmental health sciences. To achieve this, the IHSFC also develops cutting edge environmental measurements and biological response assays for Center Members, such as our highly successful tooth based biomarker of metal exposure that reconstructs past exposure dose and exposure timing. This biomarker played a key role in our recent NIH grant success being featured in 2 successful R01s, a K award and 2 ECHO cohort grants. In the coming grant cycle, we will continue to develop additional innovative methods to comprehensively measure exposure to environment insults, facilitate access to research populations and biospecimen archives, and guide researchers to existing core services across Mount Sinai. The IHSFC does not replicate services provided by other Mount Sinai core labs. Rather, we leverage and supplement other cores, such as our Clinical Translational Science Award (CTSA) funded cores, and facilitate access to CTSA core lab assays. Overall, the IHSFC of the Mount P30 Core Center at Mount Sinai is a critical resource that allows researchers to build highly efficient and collaborative teams that can address the role of environment on health across the life course.