Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

我们要求增加每年的直接费用，以支持功绩更新的目标。我们要做的是 求婚是迈向社会神经科学未来的一次戏剧性飞跃，它处于当前 技术这项拟议的研究是创新的、雄心勃勃的，对于了解灵长类动物是如何 推而广之，人类的大脑使现实世界中的适当社交行为成为可能。我们的提案推进了 理解灵长类大脑如何通过紧密整合的、雄心勃勃的 一套4个特定目标组合在多个自由移动中同时进行无线神经生理记录 猴子在不同的社交环境中自然互动，半自动或全自动地量化社交行为 使用计算机视觉、药理学操作和神经活动的可逆扰动。致我们的 据了解，这些实验从来没有在猕猴身上尝试过。我们的飞行员数据令人信服 证明我们能做到。

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.