Biobehavioral Research Training in Symptom Science

项目摘要 症状病因学、症状体验和症状管理的科学基础 在过去的几十年里有了很大的进步。然而，人们对生物行为的基础知之甚少。 许多症状或生物和行为因素在症状期间相互作用的方式 经验。对于能有效针对两者的症状管理策略更是知之甚少 症状反应的生物和行为成分。此外，症状还会在 语境中非常有影响力的社会因素。迫切需要确定症状的社会决定因素 表达和管理可能有助于独特的生物行为表型，并构成许多 健康差距。本次培训的目的是培养5名护理学博士后和3名博士后护生。 博士后实习护士进行症状科学方面的生物行为研究。在完成 计划，受训者将拥有必要的知识和技能：1)设计和进行生物行为 对症状和健康相关结果的研究，2)使用多种方法，生物行为方法 症状的测量和症状管理策略的测试，3)检查 社会决定因素在症状表现和症状中的中介和/或调节作用 管理，4)制定和实施具有伦理学和社会性的症状研究计划 经济上不同的人群跨越疾病轨迹，以及4)将研究成果转化为 关于症状预防、评估和管理的建议。博士前课程 包括加州大学旧金山分校护理学院的标准博士要求，4门针对症状的课程(理论和 症状科学的方法，研究症状的生物行为方法，基因组学等组学方法， 和社会决定因素)，以及研究常驻。博士后学员将参加4个症状- 特定课程和其他重要选修课，以推进生物行为研究目标 在个性化的课程计划中进行了定义。他们还将有一个为更多人量身定做的研究驻场 高级研究目标和授勋目标。跨学科的教职员工群体具有重要的 在症状科学、生物学和行为研究方法的整合方面的专业知识，以及 健康的社会决定因素。该小组包括护理学院的16名教员和9名附属教员 来自加州大学旧金山分校的其他学校。为护士学者做好准备，通过严谨的 生物行为研究方面的研究培训对于改善对症状的理解是必不可少的 患者和临床医生对症状的体验和更好的管理。加州大学旧金山分校护理学院 在提供临床和转化性研究的跨学科培训方面处于独特的地位，因为 其强大的研究计划、成功的研究培训历史以及与 加州大学旧金山分校参与症状相关科学的其他部门和中心。

Project Summary The science underlying symptom etiology, the symptom experience, and symptom management has advanced substantially over the last few decades. Yet little is known about the biobehavioral underpinnings of many symptoms or the ways in which biological and behavioral factors interact during the symptom experience. Even less is known about symptom management strategies that can effectively target both biological and behavioral components of the symptom response. In addition, symptoms occur within a context of very influential social factors. There is an urgent need to identify social determinants of symptom presentation and management that may contribute to unique biobehavioral phenotypes and underlie many health disparities. The purpose of this training program is to prepare 5 predoctoral nursing students and 3 postdoctoral nurse trainees to conduct biobehavioral research in symptom science. Upon completion of the program, trainees will have the knowledge and skills necessary to: 1) design and conduct biobehavioral research on symptoms and health-related outcomes, 2) employ multi-method, biobehavioral approaches to the measurement of symptoms and the testing of symptom management strategies, 3) examine the mediating and/or moderating roles of social determinants in symptom presentation and symptom management, 4) develop and implement programs of symptom research with ethnically and socio- economically diverse populations across the illness trajectory, and 4) translate research findings into recommendations for symptom prevention, assessment and management. The predoctoral curriculum includes standard PhD requirements at UCSF School of Nursing, 4 symptom-specific courses (theories & methods of symptom science, biobehavioral methods for studying symptoms, genomics and other omics, and social determinants), and a research residency. Postdoctoral trainees will participate in the 4 symptom- specific courses and engage in other salient electives to advance biobehavioral research objectives that are defined in an individualized program plan. They will also have a research residency tailored to more advanced research aims and grantsmanship goals. The interdisciplinary faculty group has significant expertise in symptom science, the integration of biologic and behavioral research methodologies, and social determinants of health. The group includes 16 faculty in the School of Nursing and 9 affiliated faculty from other Schools at UCSF. Preparing nurse scholars to advance symptom science through rigorous research training in biobehavioral research is essential for improved understanding of the symptom experience and better management of symptoms by patients and clinicians. The UCSF School of Nursing is in a unique position to provide interdisciplinary training in clinical and translational research because of its strong research programs, its history of successful research training, and its ongoing collaboration with other Departments and Centers at UCSF that are involved in symptom-related science.