UTMB OAIC Pilot/Exploratory Studies Core (PESC)

项目总结/摘要（PESC） UTMB试点/探索性研究核心（PESC）通过支持UTMB OAIC的创新， 与我们的核心使命理解相关的新研究项目的发展和成熟 改善老年人的身体功能和独立性。PESC优先支持早期 阶段调查员，同时通过吸引知名调查员，寻求建立和扩大合作 其他学科。在之前的周期中，我们支持了高比例的早期阶段（71%）， 女性（37%）和少数民族（34%）。过去两年完成了72%的试点研究 循环导致了校外资助。 PESC资助试点项目，以及与我们更广泛的OAIC主题相一致的小型探索性项目： “将功能丧失和获得的途径转化为干预措施，以优化功能恢复， 不同的老年人口”。通过利用机构资源和国际审计和调查办公室网络合作， 力求实现以下具体目标： 1.激发与OAIC主题相关的新研究焦点。 2.监督和监测资助的项目。 3.支持新研究项目的开发。 我们会透过征集、检讨和挑选有关试验计划的优良建议， OAIC主题;确定合作和共同赞助我们研究的机会;提供早期 指导支持和从其他内审办核心和机构设施获得资源;监测 受资助研究的进展;确保人类受试者的合规性、安全性和保护; 跟踪受资助项目的成功和生产力;并提供个人指导和资源 将已完成的PESC研究转化为竞争性的外部赠款申请。 在下一个周期，我们将通过与其他NIA开展新的多中心合作来扩大我们的广度。 中心（RCMAR）和其他OAIC（维克森林），重点是扩大住院试验 老年患者、神经系统疾病和西班牙裔老龄化。

PROJECT SUMMARY/ABSTRACT (PESC) The UTMB Pilot/Exploratory Studies Core (PESC) drives the innovation of the UTMB OAIC by supporting the development and maturation of new research programs relevant to our core mission of understanding and improving physical function and independence in older adults. The PESC prioritizes support of early stage investigators, while seeking to build and extend collaborations by attracting established investigators from other disciplines. Over the previous cycles we have supported a high proportion of early stage (71%), women (37%) and minority (34%) investigators. 72% of the pilot studies completed during the past two cycles have led to extramural funding. The PESC funds pilot projects, and small exploratory projects that align with our broader OAIC theme: “Translate Pathways of Function Loss and Gain into Interventions to Optimize Functional Recovery in Diverse Geriatric Populations”. By leveraging institutional resources and OAIC-network collaborations we seek to accomplish the following specific aims: 1. Stimulate new research foci relevant to the OAIC theme. 2. Oversee and monitor the funded projects. 3. Support the development of new research programs. We will accomplish our aims by soliciting, reviewing and selecting meritorious pilot proposals relevant to the OAIC theme; identifying opportunities for collaboration and co-sponsorship of our studies; providing early mentoring support and access to resources from other OAIC cores and institutional facilities; monitoring progress of the funded studies; ensuring regulatory compliance, safety and protection of human subjects; tracking success and productivity of the funded projects; and providing individual mentoring and resources to transition completed PESC studies into competitive, external grant applications. In the next cycle we will expand our breadth by developing new multicenter collaborations with other NIA centers (RCMAR) and other OAICs (Wake Forest), with an emphasis on scaling up trials in hospitalized geriatric patients, neurologic diseases and Hispanic Aging.