Developing and Evaluating Technology to Measure PAH Fate and Exposures

项目总结-安德森项目 超级基金网站经理缺乏信息，无法选择最环保和 具有成本效益的补救策略。为了做出一个平衡的决定，他们必须了解 整个系统：他们需要知道有毒化学物质是如何进出现场的，何时何地 化学物质会移动。我们建议发现生物可利用的PAH(多环芳烃)的命运， 利用被动采样设备(PSD)技术，评估环境之间的生物可用多环芳烃通量 车厢。我们建议开发通用技术来测量多环芳烃在大气中的移动(通量)。 并从超级基金网站上撤出。我们将确定多环芳烃的运动如何随季节和潮汐变化。我们会 通过水中的扩散和平流通量量化多环芳烃进入当地环境的净移动 不同的地点，一天中的不同时间，一年中的不同季节。我们建议对这些进行测试 假设：(1)生物可用多环芳烃在超级基金沉积物-水和水-水之间的移动质量 大气界面随位置、季节和潮汐的变化而变化；(2)平流通量 生物可利用的多环芳烃占总多环芳烃通量的很大一部分。我们将把第一批方法交付给 同时量化生物可用多环芳烃进出超级基金地点的空间和时间移动 沉积物、水和空气。这些方法将帮助EPA、补救人员和站点经理确定站点的优先顺序 修复，优化其站点的修复策略，并评估这些策略的有效性。 我们建议对多环芳烃的外部暴露进行第一次被动采样腕带测量 超级基金网站附近的人。这将使利益相关者和社区对 人们的外部接触及其对距离、地理因素、住房和个人的依赖 特点。还将在补救后测试同一个人对多环芳烃的外部暴露。我们 建议检验这些假设：(3)在超级基金站点附近的社区中，人们的外部压力的大小 腕带测量的暴露取决于他们到现场的距离，他们的住房特征，以及他们的 时间-活动模式；以及(4)超级基金网站的修复将减少社区的外部 暴露在多环芳烃中。我们还将把真实世界中的化学混合物从腕带传送到Tanguay和 Tilton将在斑马鱼模型和人类肺细胞中测试生物可用混合物的毒性 文化。我们将与他们合作进行以效果为导向的分析，以确定 混合物。我们将与RT和CEC团队合作，向利益相关者和社区描述a) 外部对PAH混合物的风险敞口如何随着超级基金地点附近的位置而变化，b) 混合物的成分(如果有)可能威胁人类健康，以及c)超级基金网站的补救措施 影响当地社区对多环芳烃的外部暴露。

PROJECT SUMMARY – ANDERSON PROJECT Superfund site managers lack information that would allow them to select the most environmentally sound and cost-effective remediation strategies. To make a balanced decision, they must understand the behavior of the entire system: they need to know how toxic chemicals move into and out of the site, when and where those chemicals move. We propose to discover the fate of bioavailable PAH (polycyclic aromatic hydrocarbon), utilizing passive sampling devices (PSD) technologies, to assess bioavailable PAH flux between environmental compartments. We propose to develop generalizable technology to measure the movement (flux) of PAHs into and out of Superfund sites. We will determine how PAH movement varies with the seasons and tides. We will quantify the net movement of PAHs into the local environments via diffusive and advective flux in waters at different locations, at different times of the day, and in different seasons of the year. We propose to test these hypotheses: (1) The mass of bioavailable PAH movement between Superfund sediment-water and water- atmosphere interfaces varies as a function of location, season and tide and (2) The advective flux of bioavailable PAHs represents a significant fraction of the total PAH flux. We will deliver the first methods to concurrently quantify spatial and temporal movement of bioavailable PAHs to and from a Superfund site from sediment, water, and air. These methods will help EPA, remediators, and site managers to prioritize sites for remediation, optimize remediation strategies for their sites, and evaluate the effectiveness of those strategies. We propose to conduct the first passive sampling wristband measurements of external exposure to PAHs for people near Superfund sites. This will give stakeholders and communities a quantitative understanding of people's external exposure and its dependence on distance, geographic factors, housing, and personal characteristics. Will also test external exposure to PAHs for the same individuals after remediation. We propose to test these hypotheses: (3) In communities near Superfund sites, the magnitude of people's external wristband measured exposure depends on their distance to the site, their housing characteristics, and their time-activity patterns; and (4) Remediation of a Superfund site will diminish the community's external exposure to PAHs. We will also convey real-world chemical mixtures from the wristbands to Tanguay and Tilton, who will test the toxicity of the bioavailable mixtures in the zebrafish model and in human lung cell cultures. We will collaborate with them in effects-directed analyses to identify toxic components of the mixtures. In collaboration with the RT and CEC teams, we will describe to stakeholders and communities a) how external exposure to PAH mixtures varies as a function of location near a Superfund site, b) which components of the mixtures, if any, may threaten human health, and c) how remediation of a Superfund site influences the local community's external exposure to PAHs.