KC Donnelly Externship Admin Supplement for Ariel Robinson P42ES007380 UKSRC

项目总结 肯塔基大学超级基金研究中心(UK-SRC)提供了一个专注的、跨学科的 研究和培训环境，以应对与卤化有关的严重人类健康挑战 有机物质暴露。四个中心项目和五个核心组成拟议的UK-SRC，以进一步 除了两项环境科学外，还开展关于生活方式改变的研究(例如，营养和运动) 将重点放在对这一组问题的补救和工程解决方案的项目。由于他们的 相对化学稳定性和环境中的普遍存在，氯化有机污染物，如 多氯联苯(PCBS)和三氯乙烯(TCE)对健康构成重大风险，并持续 补救挑战，包括最大的超级基金帕迪尤卡气体扩散厂等地点 位于肯塔基州的网站。英国-SRC在下一个周期的总体重点是持续的人类健康影响 卤代有机化合物(如多氯联苯、三氯乙烯和四氯乙烯)，在这一新的供资周期中， 将纳入有关全氟烷基物质和多氟烷基物质(PFAS)的其他问题。项目包括 生物医学研究假设健康的营养和运动成分提供了一个开发平台 与环境有毒侮辱有关的疾病的初级预防战略，同时还提供 为新的风险评估范式奠定了基础。此外，新的铁基纳米结构传感、捕获和 基于仿生结合结构域和功能化膜平台的修复系统提供 在现场补救技术能力方面可持续发展的潜力。英国-SRC建议 以下目标：1)在数据管理和分析核心的推动下，加快数据驱动的发现 这将提供关于暴露的生物标记物的洞察，以产生关于关系的新信息 污染物暴露、营养摄入量、体力活动和疾病风险之间的关系；2)更好地了解 卤代有机化合物毒性的生化、分子和细胞机制 (即多氯联苯和全氟化碳)，特别注重慢性炎症性疾病和易感窗口；3) 促进明智的决定，通过先进的技术加速卤代有机化合物的清理 基于材料的技术、智能过滤器以及命运和运输科学，以降低暴露风险；4) 促进采用跨学科方法开展环境健康科学培训，以加速 复杂的面向解决方案、利益相关者参与的研究，旨在减少暴露并改善人类 健康；以及5)双向参与并提供环境健康方案活动，以 肯塔基州，特别是东肯塔基州的脆弱、社会孤立、资源不足的社区(即 阿巴拉契亚中部)，慢性炎症性疾病超过全国平均水平，暴露于 环境污染物很普遍。活动将包括社区参与的研究和创新的 通过为什么-环境倡议整合项目的方法。

PROJECT SUMMARY The University of Kentucky Superfund Research Center (UK-SRC) provides a focused, cross-disciplinary research and training environment to address critical human health challenges associated with halogenated organic substance exposures. Four center projects and five cores make up the proposed UK-SRC to further develop research on lifestyle changes (e.g., nutrition and exercise) in addition to two environmental science projects that will focus on the remediation and engineering solutions to this set of problems. Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) and trichloroethylene (TCE) pose significant health risks and enduring remediation challenges, including sites such as the Paducah Gaseous Diffusion Plant, the largest Superfund site in Kentucky. The UK-SRC’s overall focus for this next cycle is the human health impacts of persistent halogenated organics (e.g., PCBs, TCE, and tetrachloroethene (PCE), and in this new cycle of funding, additional questions about per- and polyfluoralkyl substances (PFAS) will be incorporated. Projects covering biomedical research hypothesize that healthy nutrition and exercise components provide a platform to develop primary prevention strategies for diseases associated with environmental toxic insults, while also providing the basis for new risk assessment paradigms. Further, novel iron-based, nano-structured sensing, capture and remediation systems based on biomimetic binding domains and functionalized membrane platforms offer potential for sustainable advances in technical capability for site remediation. The UK-SRC proposes the following goals: 1) to expedite data-driven discovery as facilitated by the Data Management and Analysis Core that will provide insight about biomarkers of exposures to generate new information about the relationship between pollutant exposure, nutrient intake, physical activity and disease risk; 2) to better understand the biochemical, molecular, and cellular mechanisms underlying the toxicity of halogenated organic compounds (i.e., PCBs and PFAS) with a specific focus on chronic inflammatory diseases and windows of susceptibility; 3) to foster informed decisions that expedite clean-up of halogenated organic compounds through advanced material-based technologies, smart filters, and fate and transport science to reduce exposure risks; 4) to promote and interdisciplinary approaches to environmental health science training that accelerate the impact of complex solution-oriented, stakeholder-engaged research aimed at reducing exposures and improving human health; and 5) to engage bi-directionally and provide environmental health programmatic activities to vulnerable, socially-isolated, under-resourced communities in Kentucky, especially Eastern Kentucky (i.e. Central Appalachia), where chronic inflammatory diseases exceed national averages and exposure risks to environmental pollutants are prevalent. Activities will involve community engaged research and an innovative means of integrating projects through the WHY-ENVIRONMENT initiative.