Interdisciplinary Predoctoral Training in Molecular Biophysics

摘要 这项新提案寻求对T32分子生物物理学的持续支持 科罗拉多大学博尔德分校博士前培训计划，目前已进入第19个年头。这个 生物物理学培训计划的目标是为不同的有前途的人提供特殊的培训 受训者，从而为他们在生物，化学， 工程和物理-或广泛的其他职业。39名培训教职员工包括 国际公认的资深研究人员和5位博士授予的后起之秀 系：生物化学、化学与生物工程、化学、分子、细胞与 发育生物学和物理学。这些教师和他们的学生使用最先进的生物物理学 阐明大分子结构、动力学、机理和基本方面的方法 对从单分子到活细胞的各种系统的调控，与人类健康直接相关。 生物物理学是博尔德校区研究的核心领域之一。在39名培训教师中，有22名 自该计划开始以来，我们聘用了10人，其中包括过去5年的10人。生物物理学培训计划 一直是这一增长背后的关键驱动力。培训项目，由NIH和CU联合支持 Boulder Funds，已经建立了一个蓬勃发展的生物物理社区，通过广泛的合作和 不同实验室和科室的生物物理学家之间的联合数量。此外，该计划 为生物物理学博士前学生提供高度稳健的创新培训，确保他们获得 当前和未来的成功需要广泛的跨学科基础。新加强的培训 该计划将现有计划的成功特征与旨在进一步 增加课程多样性并使学生做好准备，以便有效地驾驭不断发展的现代 劳动力。学员在第一年专注于他们的家庭博士课程，然后被任命为生物物理学 研究生课程2-3年级的实习生。所需的计划要素包括核心生物物理学 负责任的研究行为(RCR)和严谨性和再现性(R&R)方面的课程和培训。 一系列其他计划活动，其中许多是新增加的，提供批判性思维、自我效能、 技术专长，社会熟练程度，道德基础，健全的科学方法，专业技能， 团队精神和领导能力。生物物理学实习生、教师、课程和其他计划要素 定期进行评估，以便能够及时、有效地应对出现的卓越和挑战。 强有力的结果表明，该计划为以下方面提供了高效的培训和支持 生物物理学实习生：1)招聘高素质的学生和教员；2)增加 代表不足的群体的参与，3)强大的实习生出版物、毕业和职业 就业率，4)培训实验室之间的广泛合作，5)培训创新。

SUMMARY This new proposal seeks continuing support for a proven and thriving T32 Molecular Biophysics Predoctoral Training Program at the University of Colorado, Boulder (CU), currently in its 19th year. The goal of the Biophysics Training Program is to provide exceptional training to a diverse cohort of promising trainees, thereby preparing them for leading-edge research careers at the interface of Biology, Chemistry, Engineering and Physics – or for a broad range of other careers. The 39 training faculty include internationally recognized established investigators and rising young stars from 5 PhD-granting departments: Biochemistry, Chemical & Biological Engineering, Chemistry, Molecular, Cellular & Developmental Biology, and Physics. These faculty and their students use state-of-the-art biophysical approaches to elucidate fundamental aspects of macromolecular structure, dynamics, mechanism, and regulation in systems ranging from single molecules to live cells, with direct relevance to human health. Biophysics is one of the core areas of research on the Boulder campus. Of the 39 training faculty, 22 were hired since the program began, including 10 in the last 5 years. The Biophysics Training Program has been a key driving force behind this growth. The training program, jointly supported by NIH and CU Boulder funds, has established a thriving biophysical community with extensive collaborations and large numbers of joint between biophysicists in different laboratories and departments. Moreover, the program provides highly robust, innovative training for predoctoral students of biophysics, ensuring they receive a broad, interdisciplinary foundation needed for current and future success. The newly enhanced training program combines successful features of the existing program with new elements designed to further increase program diversity and prepare students to effectively navigate the constantly evolving modern workforce. Trainees focus on their home PhD program in year 1, then are appointed as Biophysics trainees in years 2-3 of their graduate studies. Required program elements include core Biophysics courses and training in Responsible Conduct of Research (RCR) and Rigor and Reproducibility (R&R). An array of other program activities, many newly added, provide training in critical thinking, self-efficacy, technical expertise, social proficiency, ethical grounding, sound scientific method, professional skills, teamwork, and leadership skills. The Biophysics trainees, faculty, courses and other program elements are regularly assessed to enable timely, effective responses to excellence and challenges as they arise. Strong outcomes indicate that the program provides highly effective training and support to Biophysics trainees, as demonstrated by 1) recruitment of high quality students and faculty, 2) increased participation by underrepresented groups, 3) strong trainee publication, graduation, and career placement rates, 4) extensive collaborations between training laboratories, and 5) training innovations.