Training in the Molecular & Genetic Epidemiology of Cancer

摘要 本提案是关于分子与遗传学博士后培训计划的竞争性更新 癌症流行病学（MGEC）。当今的癌症研究使用了非凡的工具， 了解致癌的遗传和环境原因。使用这些工具， 最大程度地需要来自具有各种背景的科学家团队的投入，包括分子生物学， 生物学、肿瘤学、医学、遗传学、流行病学和生物统计学。具有多学科背景的个人 跨这些领域的教育对这些团队的成功至关重要，因为他们可以协调 完成一些最有前途的研究所需的综合工作。然而，重点 大多数培训机会的性质使调查人员获得知识的机会有限 连接这些学科的桥梁。为了解决这个问题，我们建议延长目前的MGEC培训 从目前的R25 T机制改为T32机制。 该计划提供给优秀的博士后候选人一套教学和研究 这些机会为他们在跨学科“领域”的独立研究人员的职业生涯做好了准备， 分子和遗传流行病学导师和研究培训机会将来自 加州大学弗朗西斯科分校和凯撒医疗机构北方加州分部 Research.该计划非常适合T32赠款机制，因为它在T32培训科学家。 多个不同领域的交集。更具体地说，MGEC计划融合在一起， 互动时尚一组导师和学员与癌症研究专业知识的分子生物学， 遗传学流行病学和生物统计学该方案由三个主要组成部分定义：（1）a 涵盖重点学科及其交叉学科的专业核心课程;（2）额外的教育 与学员的研究和教育背景及兴趣互补的经验;及（3） 专注的研究项目由承诺的导师监督。每个学员还将被要求写 一份国家卫生研究院的提案作为他们职业生涯准备的一部分。以前的学员在以下方面取得了巨大成功： 发展独立的研究事业。在MGEC计划中接受培训的个人将具备以下技能 对于进一步研究他们的职业生涯至关重要，以破译癌症的原因，最终提供 关于预防和治疗这种复杂疾病的宝贵知识。

Abstract This proposal is for a competitive renewal of a post-doctoral training program in Molecular & Genetic Epidemiology of Cancer (MGEC). The current era of cancer research employs extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. Using these tools to their fullest extent requires input from teams of scientists with a variety of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with multi-disciplinary education across these fields are crucial to the success of such teams, as they can coordinate the integrated work necessary to accomplish some of the most promising research. However, the focused nature of most training opportunities provides limited opportunities for investigators to obtain knowledge that bridges these disciplines. To address this issue, we propose renewing the current MGEC training program from the current R25T mechanism to a T32 mechanism. This program offers to exceptional postdoctoral candidates a set of instructional and research opportunities that prepare them for careers as independent researchers in the interdisciplinary “field” of molecular and genetic epidemiology. Mentors and research training opportunities will come from the University of California, San Francisco and the Kaiser Permanente Northern California Division of Research. This program is well-suited to the T32 grant mechanism because it trains scientists at the intersection of multiple distinct fields. More specifically, the MGEC program blends together in a highly interactive fashion a group of mentors and trainees with cancer research expertise in molecular biology, genetics, epidemiology, and biostatistics. The program is defined by three main components: (1) a specialized core curriculum covering key disciplines and their intersections; (2) additional educational experiences to complement the research and educational backgrounds and interest of trainees; and (3) focused research projects supervised by committed mentors. Each trainee will also be required to write an NIH proposal as part of their career preparation. Previous trainees have shown great success in developing independent research careers. Individuals trained in the MGEC program will have the skills vital to furthering their careers in research to decipher the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.