Center for Molecular Imaging Technology & Translation (CMITT)

分子成像技术与翻译中心项目摘要/摘要 分子成像技术和翻译中心(CMITT)是一个国家生物医学中心 位于马萨诸塞州戈登医学成像中心(GCMI)的成像和生物工程 综合医院。在跨学科环境中工作(例如，成像和数据科学；图像 重建、处理和人工智能；药代动力学；放射化学)，CMITT的目标是 开发、验证和传播利用改变游戏规则的尖端成像技术 同时收购PET和M.CMITT提供的能力使PET/MR成为真正的协同效应 形态，包括新的放射化学、动力学建模、定量方法、图像重建和人工智能 PET和MR信号的特性。因此，CMITT推进了PET/MR的方法学，覆盖了整个范围 放射化学/放射药剂学对图像形成和处理的影响，包括断层重建和 评估/量化，为研究应用和临床翻译铺平道路。我们的开创性工作在 我们的P41在定量PET/MR中的初始资金周期Y1-4已经为一些最令人烦恼的问题提供了解决方案 影响PET/MR的问题，包括对衰减和非自愿受试者运动的可靠和准确的校正 (TR&D 1在Y1-4)。我们在PET定量和图像重建方面做出了独特的贡献 深度学习(第一至第四年的研发2)。我们还提出了新的放射性配体和新的分子测量方法， 从第一个概念到实际应用(TR&D 3在Y1-4)。因此，在这份续期申请中，我们处于 在提出和开发与使用PET的分子成像相关的新领域领先技术方面处于有利地位 而更新的tr&d1开发并提供多参数定量PET/MR成像 这些技术不仅能够实现生理性高影响的新型PET/MR，而且还将使独立的MR受益 研究。更新的tr&d2开发了一个创新的基于人工智能的数据处理管道。 在PET/MR中，包括图像重建、转移学习和不确定性估计。更新的tr&d3 利用在R&D 1和2中取得的进展，将PET/MR的应用从生理学概念转化为 在动物模型中进行测量，然后进行第一次人体研究。国家资源提供了一个独特的 拥有一支由具有丰富经验的科学家、工程师和临床医生组成的跨学科团队的环境 多种模式和学科的专业知识，支持影像科学家使用中心设施的服务 在全国各地以及加拿大和澳大利亚。CMITT将为以下人员提供广泛的培训机会 学生、博士后研究员和教职员工，并寻求推进正常功能的分子成像领域 通过积极传播新知识和新技术来预防和控制疾病。

Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation The Center for Molecular Imaging Technology and Translation (CMITT) is a National Center for Biomedical Imaging and Bioengineering located within the Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital. Working within the interdisciplinary environment (e.g., imaging and data sciences; image reconstruction, processing and AI; pharmacokinetics; radiochemistry) of the Gordon Center, the aim of the CMITT is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR. CMITT approaches PET/MR as a truly synergistic modality, with novel radiochemistry, kinetic modeling, quantitative methods, image reconstruction and AI that exploit properties of PET and MR signals. Thus CMITT advances the methodology of PET/MR and covers the entire range of radiochemistry/radiopharmacy to image formation and processing including tomographic reconstruction and estimation/quantitation, paving the way for research applications and clinical translation. Our pioneering work during the initial funding cycle, Y1-4, of our P41 in quantitative PET/MR, has provided solutions to some of the most vexing problems affecting PET/MR, including reliable and accurate corrections for attenuation and involuntary subject motion (TR&D 1 in Y1-4). We have provided unique contributions to PET quantitation and image reconstruction by using deep learning (TR&D 2 in Y1-4). We have also advanced novel radioligands and new molecular measurements, starting from first concept to actual application (TR&D 3 in Y1-4). Accordingly, in this renewal application, we are in a strong position to propose and develop new field-leading technologies pertaining to Molecular Imaging using PET and MR. The TR&D1 of the renewal develops and delivers multi-parametric quantitative PET/MR imaging technologies that not only enable physiological high-impact novel PET/MR but will also benefit standalone MR research. The TR&D2 of the renewal develops an innovative artificial intelligence-based pipeline of data processing in PET/MR, including image reconstruction, transfer learning, and uncertainty estimation. The TR&D3 of the renewal uses the developments achieved in TR&Ds 1&2 to translate applications of PET/MR from physiological concept to measurements in animal models and then on to first-in-human studies. The National Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Canada and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.