High Performance PET/CT Scanner

项目总结/摘要 该应用程序寻求ORIP高端仪器资助计划的支持， 购买高性能PET/CT扫描仪用于基础/转化/临床研究 在MGH/HST Athinoula A. Martinos生物医学成像中心。拟议文书 - Siemens Biograph Vision Quadra -具有1米长的轴向视野，并使用最新的 新一代PET探测器具有出色的飞行时间性能。一个数量级 Biograph Vision Quadra PET/CT的更高灵敏度将使现有和未来的项目受益 通过允许研究者：获得更高质量的PET图像，减少辐射暴露和/或 成像采集时间，放射性示踪剂给药后成像时间较长，同时进行 多器官动态采集，改善PET数据量化，执行多示踪剂 研究，提高PET测量的时间分辨率等。这些新的机会 将有利于我们的多学科NIH资助的研究人员正在进行的研究项目， MGH和大波士顿地区。此外，PET性能显著提高， 与高性能CT相结合，将补充传统的能力， PET/MRI和MRI扫描仪安装在Martinos中心，并将为新的 项目和合作项目，从心血管和肺部疾病， 肿瘤学和非肿瘤学全身应用。通过此次收购， SIG得到了MGH领导层、放射科和Martinos中心的支持。这 多层次的机构支持涵盖了与升级及其未来有关的各个方面 操作，包括分配仪器空间和协助安装，操作 在系统调度、会计和维护方面提供支持，最后但也是最重要的一点是， 重要的是，高达750万美元的承诺，以弥补NIH SIG奖之间的差距， 除了从MGH承诺的150，000美元资金外， 研究执行委员会负责系统的维护。后 安装后，Biograph Vision Quadra PET/CT将由Martinos中心作为 共享的核心，并提供给更广泛的研究界，无论是在MGH和 大波士顿地区。

Project Summary/Abstract This application seeks support from the ORIP High-End Instrumentation Grant program to purchase a high-performance PET/CT scanner to be used for basic/translational/clinical research at the MGH/HST Athinoula A. Martinos Center for Biomedical Imaging. The proposed instrument – Siemens Biograph Vision Quadra – has a 1-meter long axial field of view and uses the latest generation PET detectors with excellent time-of-flight performance. The one order of magnitude higher sensitivity of the Biograph Vision Quadra PET/CT would benefit existing and future projects by allowing investigators to: obtain higher quality PET images, reduce radiation exposure and/or imaging acquisition time, image longer time after radiotracer administration, perform simultaneous multi-organ dynamic acquisition, improve the PET data quantification, perform multi-tracer studies, increase the temporal resolution of the PET measurements, etc. These new opportunities will benefit the ongoing research projects of our multidisciplinary NIH-funded investigators from MGH and Greater Boston region. Furthermore, the substantially better PET performance combined with the high-performance CT will complement the capabilities of the conventional PET/MRI and MRI scanners installed at the Martinos Center and will foster opportunities for new projects and collaborations for projects ranging from cardiovascular and pulmonary diseases to oncological and non-oncological whole-body applications. The proposed purchase through this SIG is being supported by the MGH leadership, Radiology Department, and Martinos Center. This multi-level institutional support covers every aspect related to the upgrade and its future operations, including allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, and lastly but most significantly, a commitment of up to $7,500,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed fund of $150,000 from the MGH Executive Committee for Research towards the maintenance of the system. Following the installation, the Biograph Vision Quadra PET/CT will be managed by the Martinos Center as a shared core, and made available to the broader research community, both within MGH and the Greater Boston region.