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Activation Transcription Factor-4: Novel Regulator of Smooth Muscle Cell Repair and Intimal Thickening through Tenascin C

Activation Transcription Factor-4: Novel Regulator of Smooth Muscle Cell Repair and Intimal Thickening through Tenascin C
激活转录因子 4:通过腱蛋白 C 调节平滑肌细胞修复和内膜增厚
批准号:
nhmrc : 1030767
负责人:
Prof Levon Khachigian
金额:
$15.22万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

项目摘要

项目成果

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中文摘要
翻译
心血管疾病是世界上发病和死亡的最重要原因,占澳大利亚所有死亡人数的35%。平滑肌细胞生长是一系列血管增生性疾病的原因。本项目的重点是了解ATF-4作为损伤血管中SMC增殖和内膜增厚的新的关键调节因子的作用。此外,针对ATF-4的策略将促进未来控制血管疾病患者内膜增厚的治疗策略。
英文摘要
CVD represents the most important cause of morbidity and mortality in the world, accounting for 35% of all deaths in Australia. Smooth muscle cell growth accounts for a range of vascular proliferative disorders. This project focuses on understanding the role of ATF-4 as a new key regulator of SMC proliferation and intimal thickening in injured vessels. Moreover, strategies targeting ATF-4 will facilitate future therapeutic strategies to control intimal thickening in patients with vascular disease.
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会议论文
Growth Regulatory Transcriptional Networks and Novel Therapies in Vascular Pathobiology
  • 批准号:
    nhmrc : 1059123
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $18.28万
  • 财政年份:
    2020
  • 负责人:
    Prof Levon Khachigian
  • 依托单位:
Growth Regulatory Transcriptional Networks and Novel Therapies in Vascular Pathobiology
  • 批准号:
    nhmrc : GNT1059123
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $85.2万
  • 财政年份:
    2016
  • 负责人:
    Prof Levon Khachigian
  • 依托单位:
Novel Small Molecule FosB/AP-1 Inhibitors for the Prevention of Proliferative Vascular Disorders
  • 批准号:
    nhmrc : 1030769
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $22.91万
  • 财政年份:
    2012
  • 负责人:
    Prof Levon Khachigian
  • 依托单位:
Novel mechanisms of early growth response-1 activation through the epidermal growth factor receptor
  • 批准号:
    DP120101557
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $20.45万
  • 财政年份:
    2012
  • 负责人:
    Prof Levon Khachigian
  • 依托单位:
海外基金