Core 04: Pilot Projects Program

项目概要：试点项目计划核心 试点项目方案（PPP）核心的目标是增加接受以下培训的初级调查员人数： 临床和转化研究，与成熟的高级科学家团队合作，开发创新的 研究计划，以解决路易斯安那州的慢性病负担。这对我们的 地区之间存在着巨大的健康差距。为了实现这一目标，PPP核心提供了直接和重要的 为试点项目提供财政支助，使这些项目能够利用其他核心的专门知识和资源， 促进合作机构之间的实物支持，并促进教育和培训， 获奖者作为独立翻译研究者的长期成功。虽然目前的供资周期是 由于COVID的挑战，PPP资助了36个跨机构的试点项目，包括3个多- 机构，多研究者“团队科学”项目，在COVID之前，13名访问学者和赠款 发展奖。这些举措有助于在调查人员之间建立合作精神， LA CaTS试点项目获奖者的253篇同行评审手稿，117篇演讲和78项赠款 在本供资周期的头四年，共计6 960万美元。此外，11个试点项目获奖者 在家乡的学校里得到学术上的提升。在下一个五年周期中，我们将在这些成功的基础上再接再厉 并扩大受支持的初级调查员的数量，我们将优先考虑代表性不足的少数族裔， 调查人员和确定“铲准备”高度竞争的机构间计划，可以迅速竞争， 主要的联邦拨款计划。我们还将继续展望未来，优先考虑早期阶段 研究人员和临床医生，他们可以将新的概念和研究技术引入研究中心， 南海湾。为了实现这些目标，我们将实施三个具体目标。首先，我们将征求，审查， 建议为LA CaTS试点项目拨款，预计将导致高质量的临床和 校外资助的转化研究申请。我们会优先考虑早期调查员和初级调查员 教师来自代表性不足的少数族裔。第二，我们将建立跨机构的调查人员队伍 准备迅速竞争主要的联邦拨款计划，以解决现有的和新出现的疾病 影响到我们的人口，恶化了海湾南部的健康差距。第三，我们将提供机会 对于早期研究者和临床医生来说，参与新的研究培训机会并学习新的， 尖端的方法来进行，翻译和实施创新研究，包括临床试验。在 在下一个五年周期结束时，我们预计将增加受资助的年轻调查员的人数， 包括代表性不足的少数民族研究人员，他们可以支持大型多机构研究项目 和卓越中心，并确保我们能够解决我们地区的卫生保健需求和卫生差距， 使用尖端的科学方法。

Project Summary: Pilot Projects Program Core The goal of the Pilot Projects Program (PPP) Core is to increase the number of junior investigators trained in clinical and translational research that work with well-established teams of senior scientists developing innovative research programs to address the chronic disease burden in Louisiana. This is of particular significance to our region given the major health disparities. To achieve this goal, the PPP Core provides direct and significant financial support for pilot projects, enables these projects to utilize the expertise and resources of other cores, facilitates in-kind support across collaborating institutions, and fosters education and training that enhances each awardee's long-term success as an independent translational investigator. While the current funding cycle was challenging because of COVID, the PPP funded 36 pilot projects across institutions, including 3 multi- institutional, multi-investigator “team science” projects, and prior to COVID, 13 Visiting Scholar and Grant Development awards. These initiatives helped build a collaborative spirit among investigators and resulted in 253 peer reviewed manuscripts by LA CaTS Pilot Project awardees, 117 presentations, and 78 grants awarded totaling $69.6 million in the first four years of the current funding cycle. Further, 11 pilot project awardees were academically promoted at their home institution. During the next 5-year cycle we will build on these successes and expand the number of supported junior investigators where we will prioritize underrepresented minority investigators and identify “shovel-ready” highly competitive interinstitutional programs that can rapidly compete for major federal grant initiatives. We will also continue to look towards the future by prioritizing early-stage investigators and clinicians who can import novel concepts and research techniques to research centers in the Gulf South. To achieve these goals, we will implement three specific aims. In the first we will solicit, review, and recommend funding for LA CaTS Pilot Project grant awards that are expected to lead to high quality clinical and translational research applications for extramural funding. We will prioritize early-stage investigators and junior faculty from underrepresented minority populations. Second, we will build inter-institutional teams of investigators that are poised to rapidly compete for major federal grant initiatives addressing existing and emerging diseases affecting our population and worsening health disparities in the Gulf South. Third, we will provide opportunities for early-stage investigators and clinicians to engage in new research training opportunities and learn novel, cutting edge methods to conduct, translate and implement innovative research including clinical trials. At the conclusion of the next 5-year cycle we expect to have increased the number of funded young investigators, including underrepresented minority investigators who can support large multi-institutional research programs and centers of excellence and ensure that we can address health care needs and health disparities in our region using cutting edge scientific approaches.